Cognitive decline and brain amyloid-β accumulation across 3 years in adults with Down syndrome
| Autor: | Sterling C. Johnson, Patrick J. Lao, Regina M. Hardison, Sigan L. Hartley, Benjamin L. Handen, Darlynne A. Devenny, Peter Bulova, William E. Klunk, Bradley T. Christian, Iulia Mihaila |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Aging Time Factors Memory Episodic Precuneus Posterior parietal cortex Neuropathology Article Executive Function 03 medical and health sciences chemistry.chemical_compound Cognition 0302 clinical medicine Alzheimer Disease medicine Humans Dementia Cognitive Dysfunction Cognitive decline Episodic memory Amyloid beta-Peptides Aniline Compounds General Neuroscience Ventral striatum Brain Middle Aged medicine.disease Thiazoles 030104 developmental biology medicine.anatomical_structure chemistry Positron-Emission Tomography Female Neurology (clinical) Down Syndrome Geriatrics and Gerontology Psychology Pittsburgh compound B Neuroscience 030217 neurology & neurosurgery Phenanthrolines Developmental Biology |
| Zdroj: | Neurobiology of Aging. 58:68-76 |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2017.05.019 |
| Popis: | Adults with Down syndrome (DS) have a high incidence of Alzheimer's disease (AD), providing a unique opportunity to explore the early, preclinical stages of AD neuropathology. We examined change in brain amyloid-β accumulation via the positron emission tomography tracer [11C] Pittsburgh compound B (PiB) across 2 data collection cycles, spaced 3 years apart, and decline in cognitive functioning in 58 adults with DS without clinical AD. PiB retention increased in the anterior cingulate gyrus, precuneus cortex, parietal cortex, and anterior ventral striatum. Across the 2 cycles, 14 (27.5%) participants were consistently PiB+, 31 (60.8%) were consistently PiB−, and 6 (11.7%) converted from PiB− at cycle 1 to PiB+ at cycle 2. Increased global amyloid-β was related to decline in verbal episodic memory, visual episodic memory, executive functioning, and fine motor processing speed. Participants who were consistently PiB+ demonstrated worsening of episodic memory, whereas participants who were consistently PiB− evidenced stable or improved performance. Amyloid-β accumulation may be a contributor to or biomarker of declining cognitive functioning in preclinical AD in DS. |
| Databáze: | OpenAIRE |
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