Spirometric and flow-volume curve analysis in rats, and optimal parameters for estimating obstructive impairment
| Autor: | Tetsuri Kondo, Hidehiro Watanabe, Toshimori Tanigaki, Chizuko Tsuji |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
Vital capacity Physiology Bronchoconstriction Vital Capacity Positive pressure Peak Expiratory Flow Rate Pulmonary function testing Constriction FEV1/FVC ratio Forced Expiratory Volume Animals Medicine Rats Wistar Lung Methacholine Chloride Maximal Expiratory Flow-Volume Curves business.industry respiratory system Volume Curve Rats respiratory tract diseases Airway Obstruction Spirometry Anesthesia Methacholine medicine.symptom business circulatory and respiratory physiology medicine.drug |
| Zdroj: | The Journal of Physiological Sciences. 60:309-316 |
| ISSN: | 1880-6562 1880-6546 |
| Popis: | We obtained flow-volume (F-V) curves in anesthetized rats by applying positive pressure on the body surface. To obtain the best curve, tracheal intubation with either a 12 or 13 gauge catheter and a surface pressure greater than 56 cmH(2)O was necessary. Peak expiratory flow rate (PEFR) and forced vital capacity (FVC) were shown to be optimal parameters for estimation of bronchoconstriction induced by methacholine inhalation while FEV(0.05) (forced expiratory volume at 0.05 s) and FEV(0.10) were of limited usefulness for this purpose. The descending segment of the F-V curve consisted of two or three phases, with later phases shortened during bronchoconstriction. In conclusion, PEFR and FVC are optimal parameters for estimation of bronchoconstriction in rats. The decreases in PEFR and FVC may reflect constriction in large and smaller airways, respectively. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink