Effect of the nanocapsulated adjuvant Sapomax on the expression of some immune response genes
| Autor: | E. S. Omirtaeva, Vladimir Berezin, Andrey Bogoyavlenskiy, Irina A. Zaitseva, Nadezhda S. Sokolova, Aizhan Turmagambetova, Madina Alexyuk, Pavel G. Alexyuk |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Cellular immunity medicine.medical_treatment Drug Compounding Biology Virus 03 medical and health sciences Mice Th2 Cells Adjuvants Immunologic Nanocapsules Immunity Saponaria Virology medicine Animals 030304 developmental biology 0303 health sciences Mice Inbred BALB C Vaccines Innate immune system 030306 microbiology virus diseases General Medicine TLR7 Th1 Cells Immunity Innate TLR3 Immunology Cytokines Tumor necrosis factor alpha Female Adjuvant |
| Zdroj: | Archives of virology. 165(6) |
| ISSN: | 1432-8798 |
| Popis: | The use of the nanocapsulated adjuvant Sapomax increased the expression of innate immunity genes (H2Q10, Ddx58, Tyk2, Tlr3, Tlr7, and TNF) responsible for the primary recognition of influenza virus, i.e., those belonging to the RLR and TLR families; genes involved in stimulating the production of type I and III IFN and pro-inflammatory cytokines; and Th1 and Th2 cellular immunity genes (Ccr4, Ccr5, IFNγ, IL-2, IL-4, and IL-10) responsible for triggering regulatory immune mechanisms in the cell. The high immunological activity of the plant-derived nanocapsulated adjuvant Sapomax may be used to enhance the efficacy of vaccines. |
| Databáze: | OpenAIRE |
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