Mercury speciation in prenatal exposure in Slovenian and Croatian population – PHIME study

Autor: Igor Prpić, Mladen Krsnik, Janja Marc, Jana Kodrič, Milena Horvat, Alfred B. Kobal, Ingrid Falnoga, Joško Osredkar, David Neubauer, Janja Snoj Tratnik, Ajda Trdin, Fabio Barbone, Oleg Petrović, Vesna Fajon, Zdravko Špirić, Darja Mazej
Rok vydání: 2019
Předmět:
ekologija
BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences
Croatia
Slovenia
ogrožanje okolja in njegovo varstvo
Population
Physiology
chemistry.chemical_element
prenatal exposure
010501 environmental sciences
01 natural sciences
Biochemistry
Bayley Scales of Infant Development
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Pregnancy
Blood plasma
Humans
Medicine
030212 general & internal medicine
Toddler
education
Methylmercury
0105 earth and related environmental sciences
General Environmental Science
education.field_of_study
neurodevelopment
varstvo naravnih virov
business.industry
BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti
Infant
Newborn
methylmercury
Mercury
Methylmercury Compounds
Fetal Blood
Mercury (element)
speciation
chemistry
Maternal Exposure
apolipoprotein E (ApoE)
Cord blood
Population study
Female
business
udc:502/504
Zdroj: Environmental research, str. 108627-1-108627-10, Vol. 177, art. 108627, 2019
COBISS-ID: 3951911
Environmental Research
Volume 177
Environmental research. multidisciplinary journal of environmental sciences, ecology, and public health, vol. 108627, no. 177, pp. 108627-1-108627-10, 2019.
ISSN: 0013-9351
DOI: 10.1016/j.envres.2019.108627
Popis: In recent years, several studies have addressed the issue of prenatal exposure to methylmercury (MeHg); however, few have actually analysed MeHg blood concentrations. Our study population included mothers and their new-borns from Slovenia (central region; N = 584) and Croatia (coastal region; N = 234). We have measurements of total Hg (THg) and MeHg in maternal hair, maternal peripheral blood, and cord blood. Cord blood Hg concentrations were low to moderate (median THg = 1.84 ng/g and MeHg = 1.69 ng/g). The proportion of THg as MeHg (%MeHg) in maternal and cord blood varied between 4% and 100% (coefficient of variation, CV = 32%) and between 8% and 100% (CV = 20%), respectively. Our data shows that variability of %MeHg was higher at lower blood THg levels. Concentrations of MeHg in maternal blood and cord blood were highly correlated (Rs = 0.943), in the case of inorganic Hg correlation was significant but weaker (Rs = 0.198). MeHg levels in maternal blood and cord blood were positively associated with seafood intake, maternal age, and negatively associated with pre-pregnancy BMI. Additionally, MeHg in maternal blood was positively associated with plasma selenium levels, and cord blood MeHg was negatively associated with parity. The results of multiple linear regression models showed that speciation analysis provides more defined estimation of prenatal exposure in association modelling. Associations between Hg exposure and cognitive performance of children (assessed using Bayley Scales of Infant and Toddler development) adjusted for maternal or child Apolipoprotein E genotypes showed higher model R2 and lower p-values when adjusted for MeHg compared to THg. This study demonstrates that Hg speciation improves the association between exposure and possible negative health effects. Bibliografija: str. 8-10. Abstract. ARRS ARRS, NEURODYS EU
Databáze: OpenAIRE
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