Polarized Cell Division of Chlamydia trachomatis
| Autor: | Yasser M. AbdelRahman, Robert J. Belland, John V. Cox, Scot P. Ouellette |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cell division Cell Cultured tumor cells Chlamydia trachomatis medicine.disease_cause Pathology and Laboratory Medicine Chlamydia Infection Cell polarity Medicine and Health Sciences Cell Cycle and Cell Division Chlamydia lcsh:QH301-705.5 Asses Cell Analysis Mammals Budding biology Cell Polarity Cell biology Bacterial Pathogens medicine.anatomical_structure Infectious Diseases Bioassays and Physiological Analysis Cell Division Analysis Cell Processes Medical Microbiology Vertebrates Cell lines Pathogens Biological cultures Cell Division Research Article lcsh:Immunologic diseases. Allergy Cell Physiology 030106 microbiology Immunology Equines Sexually Transmitted Diseases Microbiology 03 medical and health sciences Virology Genetics medicine Animals HeLa cells FtsZ Molecular Biology Microbial Pathogens Bacteria Organisms Biology and Life Sciences Cell Biology medicine.disease Cell cultures Research and analysis methods Tubulin lcsh:Biology (General) Amniotes biology.protein Parasitology lcsh:RC581-607 |
| Zdroj: | PLoS Pathogens, Vol 12, Iss 8, p e1005822 (2016) PLoS Pathogens |
| ISSN: | 1553-7374 1553-7366 |
| Popis: | Bacterial cell division predominantly occurs by a highly conserved process, termed binary fission, that requires the bacterial homologue of tubulin, FtsZ. Other mechanisms of bacterial cell division that are independent of FtsZ are rare. Although the obligate intracellular human pathogen Chlamydia trachomatis, the leading bacterial cause of sexually transmitted infections and trachoma, lacks FtsZ, it has been assumed to divide by binary fission. We show here that Chlamydia divides by a polarized cell division process similar to the budding process of a subset of the Planctomycetes that also lack FtsZ. Prior to cell division, the major outer-membrane protein of Chlamydia is restricted to one pole of the cell, and the nascent daughter cell emerges from this pole by an asymmetric expansion of the membrane. Components of the chlamydial cell division machinery accumulate at the site of polar growth prior to the initiation of asymmetric membrane expansion and inhibitors that disrupt the polarity of C. trachomatis prevent cell division. The polarized cell division of C. trachomatis is the result of the unipolar growth and FtsZ-independent fission of this coccoid organism. This mechanism of cell division has not been documented in other human bacterial pathogens suggesting the potential for developing Chlamydia-specific therapeutic treatments. Author Summary The obligate intracellular human pathogen Chlamydia trachomatis is the leading bacterial cause of sexually transmitted infections. C. trachomatis does not express FtsZ, which is necessary for the highly conserved process of binary fission that most bacteria utilize to divide. Nonetheless, it has been assumed that this bacterial pathogen divides by binary fission. We show here that C. trachomatis divides by a polarized cell division process that is similar to the budding process of some other bacteria that lack FtsZ, such as the Planctomycetes. This novel mode of cell division has not been documented in other human bacterial pathogens suggesting the potential for developing Chlamydia-specific therapeutic treatments. |
| Databáze: | OpenAIRE |
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