Lactosucrose Inhibits Body Fat Accumulation in Rats by Decreasing Intestinal Lipid Absorption
| Autor: | Yasuhiko Takei, Satomi Koya-Miyata, Mayumi Kurose, Keizo Kohno, Akiko Mizote, Hiroto Chaen, Yoshifumi Taniguchi, Shigeharu Fukuda, Kazuyuki Oku, Kanso Iwaki |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Abdominal Fat Triacylglycerol lipase Adipose tissue Absorption (skin) Fatty Acids Nonesterified Biology Applied Microbiology and Biotechnology Biochemistry Intestinal absorption Veins Analytical Chemistry chemistry.chemical_compound Internal medicine medicine Animals Obesity Triolein Rats Wistar Pancreas Molecular Biology Triglycerides chemistry.chemical_classification Triglyceride Intestinal lipid absorption Organic Chemistry Lipase General Medicine Oligosaccharide Lipid Metabolism Rats Endocrinology Adipose Tissue Intestinal Absorption chemistry Dietary Supplements lipids (amino acids peptides and proteins) Trisaccharides Biotechnology |
| Zdroj: | Bioscience, Biotechnology, and Biochemistry. 73:582-587 |
| ISSN: | 1347-6947 0916-8451 |
| Popis: | Lactosucrose (LS, 4(G)-beta-D-galactosylsucrose) is a non-digestible oligosaccharide, and the consumption of LS selectively increases the proportion of intestinal bifidobacteria. We examined in this study the hypolipidemic potential of LS. An oral triolein tolerance test on rats indicated that LS reduced the elevation of serum triglyceride (TG) and free fatty acids (FFA). Furthermore, LS inhibited the enzymatic digestion of triolein by pancreatic lipase in vitro. NMR spectroscopy showed that LS formed an intermolecular complex with triolein. The long-term consumption of a diet containing 5% LS for 8 weeks significantly decreased the weight of abdominal adipose tissue when compared with that of the control group. Thus, LS may reduce adipose tissue accumulation by inhibiting intestinal lipid absorption via a direct interaction with TG. |
| Databáze: | OpenAIRE |
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