Human placental thyroxine inner ring monodeiodinase in complicated pregnancy
| Autor: | Shintaro Saito, Makiko Yamamoto, Kazuro Kaise, Kaoru Yoshinaga, Kitaoka H, Toshiro Sakurada, Takashi Nomura, Katsumi Yoshida, Nobuko Kaise, Nobuaki Furuhashi, Osamu Shinkawa, Tomomi Takahashi, Yoichi Itagaki, Michiko Suzuki, Hiroshi Fukazawa |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
endocrine system
medicine.medical_specialty Amniotic fluid Complications of pregnancy Triiodothyronine Reverse Endocrinology Diabetes and Metabolism Placenta Gestational Age Abortion Iodide Peroxidase Endocrinology Pregnancy Internal medicine Medicine Humans Triiodothyronine business.industry Infant Newborn Gestational age Radioimmunoassay Abortion Induced medicine.disease Amniotic Fluid Fetal Blood Abortion Spontaneous Pregnancy Complications medicine.anatomical_structure Gestation Female business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Metabolism: clinical and experimental. 34(6) |
| ISSN: | 0026-0495 |
| Popis: | Production of rT3 from T4 in the placenta were measured in four patients with induced abortion, in three patients with spontaneous abortion, in 19 patients with various complications of pregnancy including Graves' disease, and in 18 normal pregnancies. The placentas, obtained at delivery, were homogenized and centrifuged at 800 X g. Supernatants (1 mg protein) were incubated with 1 microgram of stable T4 and 50 mmol/L dithiothreitol at 37 degrees C for 60 minutes. The generated rT3 was measured by radioimmunoassay (RIA). In patients who delivered at 38 to 41 weeks with complicated pregnancy, the net placental rT3 production from T4 was 7.3 +/- 2.5 ng/tube, which was not significantly different from that obtained in normal pregnancy (8.5 +/- 2.4) at an equivalent gestational age. In patients with abortions, the net placental rT3 generation from T4 was very high, and there was a significant negative correlation between the net placental rT3 production from T4 and gestational age. These results indicate that the net placental rT3 production from T4 is not affected by complications of pregnancy, but shows a significant change with the progress of gestation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|