Genetic diversity of human immunodeficiency virus-1 in Nigeria: 2002-2017 - systematic review and meta-analysis
| Autor: | Babangida Ahmed Suleiman, Mohammed Ibrahim Tahir, Abdurrahman Elfulaty Ahmad, Ahmed Saraja Opaluwa, M. Aminu |
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| Rok vydání: | 2020 |
| Předmět: |
Recombination
Genetic Funnel plot medicine.medical_specialty Genetic diversity business.industry Human immunodeficiency virus (HIV) Genetic Variation Nigeria HIV Infections General Medicine medicine.disease_cause Confidence interval Meta-analysis Internal medicine medicine HIV-1 Humans Genetic variability business Phylogeny |
| Zdroj: | The Nigerian postgraduate medical journal. 27(1) |
| ISSN: | 1117-1936 |
| Popis: | Nigeria was ranked second highest country with human immunodeficiency virus (HIV) burden worldwide. HIV-1 subtypes and circulating recombinant forms genetic variability affect the protease and reverse transcriptase genes which code for viral enzymes and are the main targets for antiretroviral drugs. Therefore, this study was aimed at reviewing and pooling such HIV-1 subtypes in Nigeria to represent the collective prevalence of each subtype. Studies of HIV-1 subtypes in Nigeria published from 2002 to 2017 were retrieved and synthesised from different sources electronically. Sixteen studies were included for random effect meta-analysis for various subtypes in each study. The pooled prevalence was charted in forest plot and effect estimates from individual studies against some measure of study size or precision were presented in funnel plots. The pooled prevalence of Subtype G, CRF02_AG, CRF06_cpx, Subtype A and Subtype C were 38.27% (95% Confidence Interval [CI]: 21.27%- 55.98%), 37.81% (95% CI: 20.37%- 55.25%), 6.6% (95% CI: 7.10%-7.10%), 14.05% (95% CI: 9.06% - 19.04%) and 2.80% (95% CI: 2.70%- 8.30%) respectively. This study suggests HIV-1 subtypes G, CRF02_AG and A are the most prevalent in Nigeria. |
| Databáze: | OpenAIRE |
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