A population-based clinical trial with the SPf66 synthetic Plasmodium falciparum malaria vaccine in Venezuela
| Autor: | O. Noya G., Y. G. Berti, B. A. d. Noya, R. Borges, N. Zerpa, J. D. Urb ez, A. Madonna, E. Garrido, M. Auxiliadora Jimenez, R. E. Borges, P. Garcia, I. Reyes, W. Prieto, C. Colmenares, R. Pabon, T. Barraez, L. G. de Caceres, N. Godoy, R. Sifontes |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Protozoan Vaccines medicine.medical_specialty Adolescent Plasmodium vivax Molecular Sequence Data Plasmodium falciparum Protozoan Proteins Antibodies Protozoan Internal medicine parasitic diseases Malaria Vaccines Malaria Vivax Immunology and Allergy Medicine Animals Humans Amino Acid Sequence Malaria Falciparum Child Aged Autoantibodies Vaccines Synthetic biology business.industry Malaria vaccine Incidence (epidemiology) Incidence Vaccination Middle Aged biology.organism_classification medicine.disease Venezuela Confidence interval Recombinant Proteins Titer Infectious Diseases Female Seasons business Malaria Follow-Up Studies |
| Zdroj: | The Journal of infectious diseases. 170(2) |
| ISSN: | 0022-1899 |
| Popis: | A phase III malaria vaccine trial in 13 villages in an endemic area, South Venezuela, compared incidence rates of Plasmodium falciparum and Plasmodium vivax infections in 1422 vaccinated and 938 nonvaccinated subjects over 18 months. The SPf66 vaccine was given in three doses, on days 0, 20, and 112. Vaccination was complete in 976 subjects (68.7%). Minor side effects requiring no treatment were reported by 123 (12.6%), with an apparent increase in frequency from the first to the third vaccine dose. No autoimmune evidence was observed in a sample of subjects. Antibodies against SPf66 were present at low titers in 24.7% of tested subjects before vaccination, increasing to 53.6% after the second dose and to 73.6% after the third dose; 26.4% of subjects initially seronegative never seroconverted. The SPf66 malaria vaccine showed a protective efficacy of 55% (95% confidence interval, 21%-75%) against P. falciparum and of 41% (19%-57%) against P. vivax malaria. |
| Databáze: | OpenAIRE |
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