Zebrafish Primordial Germ Cell Migration
| Autor: | Adan Olguin-Olguin, Erez Raz, Anne Aalto |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
endocrine system
QH301-705.5 Somatic cell Mini Review Motility cell motility Biology Cell and Developmental Biology Cxcr4 03 medical and health sciences amoeboid migration 0302 clinical medicine Cell polarity Bleb (cell biology) chemotaxis Biology (General) Zebrafish 030304 developmental biology 0303 health sciences urogenital system chemokine fungi PGC Chemotaxis Cell Biology biology.organism_classification Embryonic stem cell Cell biology bleb cell polarity embryonic structures Cancer cell 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Frontiers in Cell and Developmental Biology, Vol 9 (2021) Frontiers in Cell and Developmental Biology |
| ISSN: | 2296-634X |
| DOI: | 10.3389/fcell.2021.684460 |
| Popis: | Similar to many other organisms, zebrafish primordial germ cells (PGCs) are specified at a location distinct from that of gonadal somatic cells. Guided by chemotactic cues, PGCs migrate through embryonic tissues toward the region where the gonad develops. In this process, PGCs employ a bleb-driven amoeboid migration mode, characterized by low adhesion and high actomyosin contractility, a strategy used by other migrating cells, such as leukocytes and certain types of cancer cells. The mechanisms underlying the motility and the directed migration of PGCs should be robust to ensure arrival at the target, thereby contributing to the fertility of the organism. These features make PGCs an excellent model for studying guided single-cell migration in vivo. In this review, we present recent findings regarding the establishment and maintenance of cell polarity that are essential for motility and discuss the mechanisms by which cell polarization and directed migration are controlled by chemical and physical cues. |
| Databáze: | OpenAIRE |
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