Does continuous subcutaneous infusion of lignocaine relieve intractable pruritus associated with advanced cutaneous T-cell lymphoma? A retrospective case series review
| Autor: | Jean Norris, James Llewellyn Barker, Odette Spruijt, Odette Buelens |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Palliative care Skin Neoplasms Infusions Subcutaneous 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine Humans Anesthetics Local Retrospective Studies business.industry Pruritus Cutaneous T-cell lymphoma Lidocaine General Medicine Middle Aged medicine.disease Dermatology Continuous subcutaneous infusion Lymphoma Lymphoma T-Cell Cutaneous Anesthesiology and Pain Medicine 030220 oncology & carcinogenesis Female business |
| Zdroj: | Palliative medicine. 33(5) |
| ISSN: | 1477-030X |
| Popis: | Background: Intractable pruritus affects an estimated 83% of patients with advanced cutaneous T-cell lymphoma. Palliative care strategies to improve outcomes for these patients are lacking. Lignocaine antagonises kappa opioid antagonist-induced scratching in mice models and may relieve cutaneous T-cell lymphoma–pruritus. Practice challenge: The aim of this retrospective case series was to evaluate our clinical experience with low-dose continuous subcutaneous infusion lignocaine for intractable pruritus associated with cutaneous T-cell lymphoma, from 2000 to 2015. The study received approval from Retrospective Review Panel, Division Cancer Medicine, 12 October 2015, V1.1. Method: Baseline demographics including cutaneous T-cell lymphoma diagnosis and management, comorbidities, and pruritus-related evaluation including onset, severity, past and current therapies were collected. Response categories (Complete, Partial, No, Unknown) were devised for the study, based on severity of pruritus, impact on sleep and mood. The mean of responses was calculated for each patient and across the series. Outcome: Nineteen patients received continuous subcutaneous infusion lignocaine, in 45 treatment episodes, ranging from 1 to 70 days (interquartile range = 5). Baseline mean number of adjuvants was 3.9 (range, 1–9). Across the series, complete response was achieved, on average, 26.7% days, partial response 49.4%, no response 16.1% and unknown response 9.2%. Drowsiness was documented in four patients. Three patients died during continuous subcutaneous infusion due to disease progression. Lessons: Continuous subcutaneous infusion lignocaine offers another therapeutic option in cutaneous T-Cell lymphoma–related intractable pruritus. Future research: Prospective studies using validated assessment tools and systematic approaches to pruritus management are required. |
| Databáze: | OpenAIRE |
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