Adipose tissue fatty acid composition and cognitive impairment

Autor: Jerzy Leppert, Karl Michaëlsson, Leif Bergkvist, Dorota Religa, Alicja Wolk, Susanna C. Larsson, Frej Stilling
Rok vydání: 2018
Předmět:
Male
medicine.medical_specialty
Docosahexaenoic Acids
Endocrinology
Diabetes and Metabolism
Population
Adipose tissue
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Internal medicine
Prevalence
Medicine
Humans
Cognitive Dysfunction
030212 general & internal medicine
Prospective Studies
Registries
education
Proportional Hazards Models
Aged
80 and over
Sweden
education.field_of_study
Nutrition and Dietetics
Arachidonic Acid
business.industry
Proportional hazards model
Incidence
Fatty Acids
Eicosapentaenoic acid
Confidence interval
Endocrinology
Cross-Sectional Studies
chemistry
Adipose Tissue
Eicosapentaenoic Acid
Docosahexaenoic acid
Relative risk
lipids (amino acids
peptides
and proteins)
Arachidonic acid
Dementia
business
030217 neurology & neurosurgery
Zdroj: Nutrition (Burbank, Los Angeles County, Calif.). 54
ISSN: 1873-1244
Popis: Objective The aim of this study was to examine the association among adipose tissue eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid (AA), and the ratios of EPA to AA and DHA to AA with impaired cognitive function. Methods This cross-sectional analysis comprised 481 men participating in the Cohort of Swedish Men-Clinical and for whom adipose tissue fatty acid composition and results from a telephone-based cognitive test were available. Impaired cognitive function was defined using a predefined cutoff on the cognitive test. Binomial log-linear regression models were used to estimate prevalence ratios. In secondary analyses, Cox proportional hazards models were used to estimate relative risk for incident dementia ascertained by linkage with population-based registers. Results We observed a graded reduction in the prevalence of impaired cognitive function across tertiles of adipose tissue EPA/AA- ratio (Ptrend = 0.01); compared with the lowest tertile, the multivariable-adjusted prevalence ratios were, respectively, 0.89 (95% confidence interval [CI], 0.67–1.17) and 0.64 (95% CI, 0.45–0.91) for the second and third tertiles. EPA, DHA, and the DHA/AA ratio showed similar patterns of association; however, the CIs included the null. AA alone was not associated with impaired cognitive function. Although with lower precision, estimates obtained from the prospective analysis were broadly consistent with the main analysis. Conclusions Findings from this study suggest that a high ratio of EPA to AA in adipose tissue may be associated with better cognitive function. A similar association was observed with EPA, DHA, and the ratio of DHA to AA, but the results did not exclude a null association.
Databáze: OpenAIRE
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