Adipose tissue fatty acid composition and cognitive impairment
Autor: | Jerzy Leppert, Karl Michaëlsson, Leif Bergkvist, Dorota Religa, Alicja Wolk, Susanna C. Larsson, Frej Stilling |
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Rok vydání: | 2018 |
Předmět: |
Male
medicine.medical_specialty Docosahexaenoic Acids Endocrinology Diabetes and Metabolism Population Adipose tissue 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Risk Factors Internal medicine Prevalence Medicine Humans Cognitive Dysfunction 030212 general & internal medicine Prospective Studies Registries education Proportional Hazards Models Aged 80 and over Sweden education.field_of_study Nutrition and Dietetics Arachidonic Acid business.industry Proportional hazards model Incidence Fatty Acids Eicosapentaenoic acid Confidence interval Endocrinology Cross-Sectional Studies chemistry Adipose Tissue Eicosapentaenoic Acid Docosahexaenoic acid Relative risk lipids (amino acids peptides and proteins) Arachidonic acid Dementia business 030217 neurology & neurosurgery |
Zdroj: | Nutrition (Burbank, Los Angeles County, Calif.). 54 |
ISSN: | 1873-1244 |
Popis: | Objective The aim of this study was to examine the association among adipose tissue eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid (AA), and the ratios of EPA to AA and DHA to AA with impaired cognitive function. Methods This cross-sectional analysis comprised 481 men participating in the Cohort of Swedish Men-Clinical and for whom adipose tissue fatty acid composition and results from a telephone-based cognitive test were available. Impaired cognitive function was defined using a predefined cutoff on the cognitive test. Binomial log-linear regression models were used to estimate prevalence ratios. In secondary analyses, Cox proportional hazards models were used to estimate relative risk for incident dementia ascertained by linkage with population-based registers. Results We observed a graded reduction in the prevalence of impaired cognitive function across tertiles of adipose tissue EPA/AA- ratio (Ptrend = 0.01); compared with the lowest tertile, the multivariable-adjusted prevalence ratios were, respectively, 0.89 (95% confidence interval [CI], 0.67–1.17) and 0.64 (95% CI, 0.45–0.91) for the second and third tertiles. EPA, DHA, and the DHA/AA ratio showed similar patterns of association; however, the CIs included the null. AA alone was not associated with impaired cognitive function. Although with lower precision, estimates obtained from the prospective analysis were broadly consistent with the main analysis. Conclusions Findings from this study suggest that a high ratio of EPA to AA in adipose tissue may be associated with better cognitive function. A similar association was observed with EPA, DHA, and the ratio of DHA to AA, but the results did not exclude a null association. |
Databáze: | OpenAIRE |
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