Vascular calcification is not related to serum fetuin-A and osteopontin levels in hemodialysis patients
| Autor: | Ozkan Ulutas, Ali Dogan, Hulya Taskapan, Mehmet Cagatay Taskapan, Tamer Baysal |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Nephrology medicine.medical_specialty alpha-2-HS-Glycoprotein Urology medicine.medical_treatment 030232 urology & nephrology Parathyroid hormone 030204 cardiovascular system & hematology Gastroenterology Diabetes Complications 03 medical and health sciences 0302 clinical medicine Renal Dialysis Risk Factors Internal medicine Diabetes mellitus Humans Medicine Osteopontin Vitamin D Vascular Calcification Dialysis Aged biology business.industry Age Factors Odds ratio Middle Aged medicine.disease Radiography Parathyroid Hormone Case-Control Studies biology.protein Kidney Failure Chronic Female Hemodialysis business Kidney disease |
| Zdroj: | International Urology and Nephrology. 50:137-142 |
| ISSN: | 1573-2584 0301-1623 |
| Popis: | Vascular calcification (VC) in hemodialysis (HD) patients is a sign of severe cardiovascular disease and can predict cardiovascular outcomes. Fetuin-A and osteopontin (OPN) inhibit VC. Serum fetuin-A levels are lower in patients with end-stage kidney disease (ESKD) and in those who are on chronic HD therapy. However, there are limited data concerning OPN in patients who are on dialysis. The aim of our study was to determine VC in HD patients, the relationship between VC and 25-OH-vitamin D, fetuin-A, and OPN levels, and independent predictors of VC. Ninety-three patients with ESKD on HD therapy were recruited. Among these patients, 44 were male and 49 were female. The patient group was compared with a group of 20 healthy controls of similar age and sex. A plain radiograph of the hand was taken using a mammography machine for the evaluation of VC. Serum fetuin-A, OPN, and 25-OH-vitamin D levels of both patients and controls were measured. VC was detected in 45 (48.4%) HD patients. When patients were compared with healthy controls, fetuin-A levels (p |
| Databáze: | OpenAIRE |
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