Efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen in the treatment of periodontitis in patients with diabetes: a randomized clinical trial
| Autor: | María Claudia Espinel-Bermúdez, José Antonio Robles-Cervantes, Sandra O. Hernández-González, Arieh R Mercado-Sesma, Rocío Patricia Mariaud-Schmidt, Juan Ramón Gómez-Sandoval, Vianeth del Carmen Martínez-Rodríguez, Karina Celia Morgado-Castillo |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Endocrinology Diabetes and Metabolism periodontal disease Type 2 diabetes Clinical Care/Education/Nutrition Gastroenterology antibiotics law.invention 0302 clinical medicine Randomized controlled trial law 030212 general & internal medicine Clindamycin Middle Aged Prognosis Anti-Bacterial Agents Drug Therapy Combination Female type 2 diabetes medicine.symptom medicine.drug Adult medicine.medical_specialty Adolescent Bleeding on probing 030209 endocrinology & metabolism Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences Young Adult Double-Blind Method Internal medicine Metronidazole medicine Humans Periodontitis Aged business.industry Amoxicillin medicine.disease RC648-665 Chronic periodontitis Regimen Diabetes Mellitus Type 2 business Follow-Up Studies |
| Zdroj: | BMJ Open Diabetes Research & Care BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020) |
| ISSN: | 2052-4897 |
| Popis: | ObjectiveTo determine the efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen during nonsurgical treatment of periodontitis in patients with type 2 diabetes mellitus.Research design and methodsIn this double-blind, randomized clinical trial, a total of 42 patients with chronic periodontitis and type 2 diabetes were included. Patients were randomly assigned to treatment with either clindamycin or amoxicillin-metronidazole three times a day during 7 days. Clinical determinations (probing depth, bleeding on probe, and plaque index) were performed to determine the extent and severity of periodontitis before and after the pharmacological treatment.ResultsAfter 7 days of administration of clindamycin or amoxicillin-metronidazole, no differences were observed between the clinical determinations, probing depth (0.44 vs 0.50 mm, p=0.624), plaque index (17.62 vs 15.88%, p=0.910), and bleeding on probing (16.12 vs 22.17%, p=0.163), respectively. There were no adverse events in either group.ConclusionThe administration during 7 days of clindamycin or amoxicillin/metronidazole showed the same efficacy for the reduction of probing depth, plaque index, and bleeding on probing in patients with periodontitis and type 2 diabetes. |
| Databáze: | OpenAIRE |
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