Genetic screening for cerebellar abiotrophy, severe combined immunodeficiency and lavender foal syndrome in Arabian horses in Poland
| Autor: | Agata Piestrzyńska Kajtoch, Agnieszka Fornal, Monika Stefaniuk-Szmukier, Katarzyna Piórkowska, Katarzyna Ropka-Molik, Monika Bugno-Poniewierska |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Leber Congenital Amaurosis Population Biology Cerebellar Diseases medicine Animals Genetic Predisposition to Disease Genetic Testing Horses Allele education Cerebellar abiotrophy Genetic testing Genetics education.field_of_study Severe combined immunodeficiency General Veterinary medicine.diagnostic_test Lavender foal syndrome Syndrome medicine.disease people.cause_of_death Breed Pedigree Minor allele frequency Female Horse Diseases Severe Combined Immunodeficiency Animal Science and Zoology Poland people |
| Zdroj: | The Veterinary Journal. 248:71-73 |
| ISSN: | 1090-0233 |
| DOI: | 10.1016/j.tvjl.2019.04.012 |
| Popis: | The highly selective breeding of Arabian horses results in inbreeding depression and genetic disorders, thereby causing significant economic loss. The Polish population of Arabians has a great impact on many breeding programmes. The aim of the current study was to monitor genetic variants involved in the most common genetic disorders of this breed. A total of 808 elite Arabian horses were screened for cerebellar abiotrophy (CA), severe combined immunodeficiency (SCID) and lavender foal syndrome (LFS) genetic disorders by Sanger sequencing and allelic discrimination methods. The investigated population was clear of LFS. The unfavourable SCID allele was detected in three heterozygous horses (q = 0.00185). Regarding CA, the minor allele frequency was q = 0.04029. This is the first report of SCID carriers in Poland. This investigation demonstrates the value of genetic testing to support breeding decisions and to facilitate genetic disease monitoring. |
| Databáze: | OpenAIRE |
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