Thyroxine modifies the effects of growth hormone in Ames dwarf mice
Autor: | Andrzej Bartke, Michal M. Masternak, Adam Gesing, Vinal Menon, Liou Y. Sun, Denise S. Wiesenborn, Andrew Do, Xu Zhi, Adam Spong |
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Rok vydání: | 2015 |
Předmět: |
Male
Aging medicine.medical_specialty Adipose Tissue White medicine.medical_treatment Longevity Gene Expression Dwarfism Adipose tissue 030209 endocrinology & metabolism White adipose tissue Biology Mice 03 medical and health sciences 0302 clinical medicine Thyroid-stimulating hormone Internal medicine medicine Animals Drug Interactions Muscle Skeletal 030304 developmental biology 0303 health sciences Insulin Skeletal muscle Cell Biology medicine.disease Prolactin Thyroxine Insulin receptor Endocrinology medicine.anatomical_structure Liver Growth Hormone biology.protein Female Signal Transduction Research Paper |
Zdroj: | Aging (Albany NY) |
ISSN: | 1945-4589 |
Popis: | Ames dwarf (df/df) mice lack growth hormone (GH), thyroid stimulating hormone and prolactin. Treatment of juvenile df/df mice with GH alone stimulates somatic growth, reduces insulin sensitivity and shortens lifespan. Early‐life treatment with thyroxine (T4) alone produces modest growth stimulation but does not affect longevity. In this study, we examined the effects of treatment of juvenile Ames dwarf mice with a combination of GH + T4 and compared them to the effects of GH alone. Treatment of female and male dwarfs with GH + T4 between the ages of 2 and 8 weeks rescued somatic growth yet did not reduce lifespan to match normal controls, thus contrasting with the previously reported effects of GH alone. While the male dwarf GH + T4 treatment group had no significant effect on lifespan, the female dwarfs undergoing treatment showed a decrease in maximal longevity. Expression of genes related to GH and insulin signaling in the skeletal muscle and white adipose tissue (WAT) of female dwarfs was differentially affected by treatment with GH + T4 vs. GH alone. Differences in the effects of GH + T4 vs. GH alone on insulin target tissues may contribute to the differential effects of these treatments on longevity. |
Databáze: | OpenAIRE |
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