Evaluation of the pharmacokinetics, safety and clinical efficacy of sertraline used to treat social anxiety
| Autor: | Laura Mercolini, Roberto Mandrioli, Maria Augusta Raggi |
|---|---|
| Přispěvatelé: | Roberto Mandrioli, Laura Mercolini, Maria Augusta Raggi |
| Rok vydání: | 2013 |
| Předmět: |
PHARMACOKINETICS
medicine.medical_specialty Psychotherapist Drug Evaluation Preclinical MEDLINE Toxicology SERTRALINE behavioral disciplines and activities Pharmacotherapy Pharmacokinetics mental disorders Humans Medicine Clinical efficacy Psychiatry Randomized Controlled Trials as Topic Pharmacology Sertraline business.industry Social anxiety PHARMACOTHERAPY General Medicine Serotonin reuptake Anxiety Disorders SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIS) Clinical trial Phobic Disorders social anxiety business human activities Selective Serotonin Reuptake Inhibitors Half-Life medicine.drug |
| Zdroj: | Expert Opinion on Drug Metabolism & Toxicology. 9:1495-1505 |
| ISSN: | 1744-7607 1742-5255 |
| Popis: | Introduction. Social Anxiety Disorder (SAD) is an emerging, often invalidating, syndrome with deep personal, social and psychological implications. While multiple treatment strategies exist, presently none of them can be considered superior to all others. Areas covered. The aim of this review is to provide the latest information on sertraline (SRT), one of the most important Selective Serotonin Reuptake Inhibitors (SSRIs) currently used for the pharmacological therapy of SAD. A literature search has been carried out with the keywords "sertraline", "social anxiety", "social phobia" and "clinical trials". In this process, particular attention has been paid to the pharmacokinetic characteristics of the drug and its safety in clinical use. Expert opinion. SRT is an effective drug in the treatment of SAD, especially when used in combination with some form of psychological support. While it does not seem to be significantly more effective than other SSRIs, SRT scould offer some peculiar advantages: for example, it has a long half-life, allowing a single daily administration, and seems to be particularly indicated for the control of specific symptoms of SAD. |
| Databáze: | OpenAIRE |
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