Casein kinase II inhibitors isolated from two Brazilian plants Hymenaea parvifolia and Wulffia baccata
| Autor: | Masami Ishibashi, Kenzo Ohtsuki, Hiroko Oda, Kanki Komiyama, Sérgio de Mello Alves, Emi Okuyama, Takashi Watanabe, Toshiro Maekawa, Kiichiro Kawaguchi, Mana Mitamura |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Ribosomal Proteins
Flavonols Clinical Biochemistry Flavonoid Pharmaceutical Science Pharmacognosy Protein Serine-Threonine Kinases Biochemistry Triterpene Drug Discovery Enzyme Inhibitors Phosphorylation Rosales Casein Kinase II Molecular Biology chemistry.chemical_classification Flavonoids Chemistry Organic Chemistry Terpenoid Triterpenes Plant Leaves Enzyme Polyphenol visual_art visual_art.visual_art_medium Molecular Medicine Bark Casein kinase 2 Brazil |
| Zdroj: | Bioorganicmedicinal chemistry letters. 9(15) |
| ISSN: | 0960-894X |
| Popis: | Two dihydroflavonol rhamnosides (1 and 2) isolated from the bark of Hymenaea parvifolia and two pentacyclic triterpenoids (3 and 6) obtained from the leaves of Wulffia baccata have been found to exhibit inhibitory effects of casein kinase II (CK-II) dose-dependently, suggesting that at higher doses more than 10 μM, these four compounds may act as potent CK-II suppressors of the CK-II mediated activation of 60S acidic ribosomal P proteins in vitro. |
| Databáze: | OpenAIRE |
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