Antibodies to carbonic anhydrase in patients with connective tissue diseases: relationship with lung involvement
| Autor: | M. Vadacca, L. Arcarese, Pellegrino Nm, Bruno Beomonte Zobel, Francesca Buzzulini, Antonella Afeltra, Amelia Rigon, D. Zennaro, Domenico Caccavo, Antonio Amoroso |
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| Rok vydání: | 2008 |
| Předmět: |
musculoskeletal diseases
Adult Lung Diseases Male Pathology medicine.medical_specialty Immunology Connective tissue Psoriatic arthritis medicine Immunology and Allergy Humans Carbonic Anhydrase I Connective Tissue Diseases Aged Autoantibodies Carbonic Anhydrases Pharmacology biology Receiver operating characteristic business.industry Interstitial lung disease Complement C4 Complement C3 respiratory system Middle Aged medicine.disease respiratory tract diseases lung involvement connective tissue diseases anti-carbonic anhydrase medicine.anatomical_structure C-Reactive Protein Rheumatoid arthritis biology.protein Female CTD Antibody business Tomography X-Ray Computed |
| Zdroj: | Scopus-Elsevier Europe PubMed Central |
| ISSN: | 0394-6320 |
| Popis: | The aim of this study is to evaluate the presence of antibodies to carbonic anhydrase I and/or II (ACAI and ACAII) in patients affected by connective tissue diseases (CTD) and to investigate their association with lung involvement evaluated by High resolution CT scan (HRCT). Ninety-six patients affected by CTD were studied, i.e. 33 rheumatoid arthritis (RA), 8 psoriatic arthritis (PA), 8 ankylosing spondilitis (AS), 23 Systemic Lupus Erythematosus (SLE), 10 Sjogren Syndrome (SS), and 14 Systemic Sclerosis (SSc). ACA were detected by ELISA. The lung involvement was evaluated by means of a previously described HRCT score. According to a receiver operator characteristic curve, patients were divided into those with HRCT score ≥ 10 and those with HRCT score < 10, where HRCT score ≥ 10 was predictive of interstitial lung disease. ACAI and/or ACAII were detected in 30/96 patients (31.2%) (P |
| Databáze: | OpenAIRE |
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