Exhaled Nitric Oxide in Children with Asthma and Short-Term PM2.5 Exposure in Seattle

Autor: Karen Jansen, Thomas Lumley, Therese F. Mar, Timothy V. Larson, Kristen Shepherd, Jane Q. Koenig
Jazyk: angličtina
Rok vydání: 2005
Předmět:
Time Factors
short-term exposure
Health
Toxicology and Mutagenesis
Respiratory System
010501 environmental sciences
airway inflammation
01 natural sciences
Gastroenterology
chemistry.chemical_compound
0302 clinical medicine
Child
Air Pollutants
Chemistry
Airway inflammation
Age Factors
Temperature
Environmental exposure
Particulates
respiratory system
Breath Tests
Children's Health
Washington
medicine.medical_specialty
Nitric Oxide
complex mixtures
Nitric oxide
particulate matter less than or equal to 2.5 μm
03 medical and health sciences
Air pollutants
children
Internal medicine
medicine
Humans
Particle Size
0105 earth and related environmental sciences
Asthma
Inflammation
Models
Statistical
Research
Public Health
Environmental and Occupational Health
Humidity
Environmental Exposure
asthma
medicine.disease
Surgery
respiratory tract diseases
030228 respiratory system
13. Climate action
Exhaled nitric oxide
exhaled nitric oxide
Zdroj: Environmental Health Perspectives
ISSN: 1552-9924
0091-6765
Popis: The objective of this study was to evaluate associations between short-term (hourly) exposures to particulate matter with aerodynamic diameters2.5 microm (PM2.5) and the fractional concentration of nitric oxide in exhaled breath (FE(NO) in children with asthma participating in an intensive panel study in Seattle, Washington. The exposure data were collected with tapered element oscillation microbalance (TEOM) PM2.5 monitors operated by the local air agency at three sites in the Seattle area. FE(NO) is a marker of airway inflammation and is elevated in individuals with asthma. Previously, we reported that offline measurements of FE(NO) are associated with 24-hr average PM2.5 in a panel of 19 children with asthma in Seattle. In the present study using the same children, we used a polynomial distributed lag model to assess the association between hourly lags in PM2.5 exposure and FE(NO) levels. Our model controlled for age, ambient NO levels, temperature, relative humidity, and modification by use of inhaled corticosteroids. We found that FE(NO) was associated with hourly averages of PM2.5 up to 10-12 hr after exposure. The sum of the coefficients for the lag times associated with PM2.5 in the distributed lag model was 7.0 ppm FE(NO). The single-lag-model FE(NO) effect was 6.9 [95% confidence interval (CI), 3.4 to 10.6 ppb] for a 1-hr lag, 6.3 (95% CI, 2.6 to 9.9 ppb ) for a 4-hr lag, and 0.5 (95% CI, -1.1 to 2.1 ppb) for an 8-hr lag. These data provide new information concerning the lag structure between PM2.5 exposure and a respiratory health outcome in children with asthma.
Databáze: OpenAIRE
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