FGF23, Biomarker or Target?
| Autor: | Cristian Rodelo-Haad, Rafael Santamaria, M. Victoria Pendón-Ruiz de Mier, Mariano Rodriguez, Alejandro Martin-Malo, Juan R. Muñoz-Castañeda |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Fibroblast growth factor 23
Health Toxicology and Mutagenesis Population 030232 urology & nephrology lcsh:Medicine Review Toxicology Bioinformatics urologic and male genital diseases Klotho Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Medicine parathyroid hormone Animals Humans fibroblast growth factor 23 (FGF23) education Adverse effect 030304 developmental biology phosphate 0303 health sciences education.field_of_study calcium business.industry lcsh:R fibroblast growth factor 23 (FGF23) fibroblast growth factor receptor (FGFR) Klotho medicine.disease Blockade Fibroblast Growth Factors stomatognathic diseases Fibroblast Growth Factor-23 medicine.anatomical_structure Erythropoietin dialysis Hyperparathyroidism Secondary Bone marrow business fibroblast growth factor receptor (FGFR) chronic kidney disease Biomarkers Kidney disease medicine.drug |
| Zdroj: | Toxins, Vol 11, Iss 3, p 175 (2019) Toxins |
| Popis: | Fibroblast growth factor 23 (FGF23) plays a key role in the complex network between the bones and other organs. Initially, it was thought that FGF23 exclusively regulated phosphate and vitamin D metabolism; however, recent research has demonstrated that an excess of FGF23 has other effects that may be detrimental in some cases. The understanding of the signaling pathways through which FGF23 acts in different organs is crucial to develop strategies aiming to prevent the negative effects associated with high FGF23 levels. FGF23 has been described to have effects on the heart, promoting left ventricular hypertrophy (LVH); the liver, leading to production of inflammatory cytokines; the bones, inhibiting mineralization; and the bone marrow, by reducing the production of erythropoietin (EPO). The identification of FGF23 receptors will play a remarkable role in future research since its selective blockade might reduce the adverse effects of FGF23. Patients with chronic kidney disease (CKD) have very high levels of FGF23 and may be the population suffering from the most adverse FGF23-related effects. The general population, as well as kidney transplant recipients, may also be affected by high FGF23. Whether the association between FGF23 and clinical events is causal or casual remains controversial. The hypothesis that FGF23 could be considered a therapeutic target is gaining relevance and may become a promising field of investigation in the future. |
| Databáze: | OpenAIRE |
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