Aplastic Anaemia Associated with Anti-Tuberculosis Chemotherapy
| Autor: | E.A. Aderoju, G. Sekoni, C.K.O. Williams, A.D. Adenle, G.J.F. Esan |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Antitubercular Agents Nigeria Gastroenterology Tuberculosis Laryngeal Anti tuberculosis Internal medicine Isoniazid medicine Humans Tuberculosis Pulmonary Thioacetazone Chemotherapy business.industry Bone marrow failure Anemia Aplastic Pyridoxine Hematology General Medicine Aplasia Middle Aged medicine.disease Aminosalicylic Acid Discontinuation medicine.anatomical_structure Streptomycin Acridines Drug Therapy Combination Female Bone marrow business medicine.drug |
| Zdroj: | Acta Haematologica. 68:329-332 |
| ISSN: | 1421-9662 0001-5792 |
| Popis: | 3 cases of aplastic anaemia occurring in association with anti-tuberculosis chemotherapy are reported. The patients had been on anti-tuberculosis chemotherapy for 13, 11 and 14 months, respectively, prior to the diagnosis of aplastic anaemia. Agents used included streptomycin, thiacetazone, isoniazid, p-aminosalicylic acid and dimethylcarbazine. Recovery from aplasia did not occur 6. 1.5 and 0.8 months, respectively, after the discontinuation of the suspect myelotoxic agents and despite the use of myelostimulatory agents. All 3 patients died of haemorrhage secondary to thrombocytopenia. The observations are consistent with a protracted and probably irreversible damage of the bone marrow by anti-tuberculosis agent(s) in susceptible individuals. |
| Databáze: | OpenAIRE |
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