| Popis: |
The healing of cutaneous wounds of mice was examined by immunofluorescent, phase, and electron microscopy. The results suggested that the epithelial basement membrane appeared to undergo degradation early in the healing process and did not regain all characteristics until remodeling of the redundant epidermis was completed. It did not appear to function as a substratum for epithelial migration; instead it appeared that the basement membrane may be partially responsible for the maintenance of the microenvironment of the epidermis. Phase micrographs illustrated a large number of degenerating basal cells at the completion of reepithelialization. These cells were confined to the basal layer and suggested that wound remodeling was initiated by selective cell death. |
