Biotransformation of methyl tert-butyl ether by human cytochrome P450 2A6
| Autor: | Tahereh Poursaberi, Fereshteh Chitsazian, S. Mojtaba Mostafavi, Ali Akbar Miran Beigi, Mohammad Teymouri, Shahram Abolhassan Tash, Parviz Soleimani, Mojtaba Shamsipur |
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| Rok vydání: | 2011 |
| Předmět: |
Methyl Ethers
Environmental Engineering Metabolite Bioengineering Alcohol Ether Microbiology Gas Chromatography-Mass Spectrometry Substrate Specificity chemistry.chemical_compound Cytochrome P-450 Enzyme System Biotransformation Humans Environmental Chemistry Octane rating CYP2A6 Chromatography High Pressure Liquid Oxygenate Pollution Kinetics Biochemistry chemistry Biocatalysis Microsomes Liver Metabolic Networks and Pathways Methyl tert-butyl ether |
| Zdroj: | Biodegradation. 23:311-318 |
| ISSN: | 1572-9729 0923-9820 |
| DOI: | 10.1007/s10532-011-9510-0 |
| Popis: | Methyl tert-butyl ether (MTBE) is widely used as gasoline oxygenate and octane number enhancer for more complete combustion in order to reduce the air pollution caused by motor vehicle exhaust. The possible adverse effects of MTBE on human health are of major public concern. However, information on the metabolism of MTBE in human tissues is scarce. The present study demonstrates that human cytochrome P450 2A6 is able to metabolize MTBE to tert-butyl alcohol (TBA), a major circulating metabolite and marker for exposure to MTBE. As CYP2A6 is known to be constitutively expressed in human livers, we infer that it may play a significant role in metabolism of gasoline ethers in liver tissue. |
| Databáze: | OpenAIRE |
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