Corticotropin-Releasing Factor: its Action on the Islets of Langerhans
| Autor: | C. P. Fawcett, J. H. Moltz |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Corticotropin-Releasing Hormone medicine.medical_treatment Peptide Peptide hormone Biology Glucagon Islets of Langerhans Endocrinology Culture Techniques Internal medicine Insulin Secretion medicine Animals Insulin Secretion chemistry.chemical_classification geography geography.geographical_feature_category Dose-Response Relationship Drug Biological activity General Medicine Islet In vitro Rats chemistry Secretory Rate hormones hormone substitutes and hormone antagonists |
| Zdroj: | Endocrine Research. 11:87-93 |
| ISSN: | 1532-4206 0743-5800 |
| DOI: | 10.3109/07435808509035427 |
| Popis: | Synthetic rat and ovine CRF were tested in an in vitro isolated pancreatic islet system for their ability to influence insulin and glucagon release. Acute exposure of islets to both rat and ovine CRF resulted in a significant increase in glucagon release but only over a narrow range of concentration (50-200 pg/ml). Neither peptide had a significant effect on insulin release. Our results raise the possibility that release of glucagon may be stimulated by CRF as part of the overall response to stress. |
| Databáze: | OpenAIRE |
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