The development of a clinical score for the prediction of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease using routine parameters
| Autor: | Qiu Chunwu, Yang Lijun, Huang Xiaoyun, Yu Xuejun, Li Chunming, Zhang Hongguang, Sheng Jianhui |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Apolipoprotein B Severity of Illness Index digestive system Gastroenterology Liver Function Tests Non-alcoholic Fatty Liver Disease Predictive Value of Tests Internal medicine Nonalcoholic fatty liver disease medicine Humans Apolipoproteins B Retrospective Studies Ultrasonography biology Receiver operating characteristic medicine.diagnostic_test Diagnostic Tests Routine business.industry Fatty liver Area under the curve nutritional and metabolic diseases Alanine Transaminase gamma-Glutamyltransferase Middle Aged medicine.disease digestive system diseases C-Reactive Protein Liver ROC Curve Predictive value of tests biology.protein Abnormal Liver Function Test Female business Liver function tests Biomarkers |
| Zdroj: | The Turkish Journal of Gastroenterology. 26:408-416 |
| ISSN: | 2148-5607 1300-4948 |
| DOI: | 10.5152/tjg.2015.6336 |
| Popis: | Background/aims To develop a clinical score for the prediction of nonalcoholic steatohepatitis (NASH) using routine parameters in patients with nonalcoholic fatty liver disease who had abnormal liver function tests and/or fatty liver detected by ultrasonography. Materials and methods To identify parameters associated with the presence of NASH by evaluating anthropometric characteristics and routine biomarkers of 82 patients with histologically proven NAFLD and to develop a clinical score for predicting NASH according to the area under the curve of receiver operating characteristics (AUC) of parameters. Results Four parameters [alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), C-reactive protein (CRP), and apolipoprotein B (ApoB)/apolipoprotein A1 (ApoA1) ratio] were significantly linked to NASH. The AUROCs of ALT, GGT, CRP, and ApoB/ApoA1 ratio for the prediction of NASH were 0.829, 0.892, 0.708, and 0.712, respectively. The AUROC of the combined clinical score for the prediction of NASH was 0.904 (95% CI, 0.885-1.002) at a cut-off of 3.8 points with a sensitivity of 90.2%, specificity of 87.0%, positive predictive value of 88.3%, and negative predictive value of 91.5%. Conclusion In the present study, a clinical score was developed for the noninvasive prediction of NASH; the score was based on a combination of routine biochemical parameters and was useful in distinguishing NASH from NAFLD. |
| Databáze: | OpenAIRE |
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