Histocompatibility Antigens and Humoral Immunity to Epstein-Barr Virus
| Autor: | Kenneth M. Boyer, Max R. Mickey, Ciro V. Sumaya, Mary J. Spencer, Paul I. Terasaki, James D. Cherry |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Epstein-Barr Virus Infections Herpesvirus 4 Human Immunology Human leukocyte antigen medicine.disease_cause complex mixtures Biochemistry Virus ABO Blood-Group System Capsid HLA Antigens Seroepidemiologic Studies ABO blood group system Genetics medicine Humans Immunology and Allergy Antigens Viral biology General Medicine Middle Aged Epstein–Barr virus Virology Histocompatibility Titer Antibody Formation Humoral immunity biology.protein Female Antibody |
| Zdroj: | Tissue Antigens. 15:105-111 |
| ISSN: | 1399-0039 0001-2815 |
| Popis: | To explore possible genetic determinants of immunity to Epstein-Barr (EB) virus infection, prevalence rates and geometric mean titers (GMT) of antibody against EB viral capsid antigen (VCA) were measured in 422 adults of known HLA and ABO histocompatibility types. Deviation from the overall prevalence (87%) of anti-VCA titers > 10 was limited to subjects with HLA-A10 (95%) and those with a "blank" HLA-A locus (78%). The latter deviation was largely accounted for by the 13 subjects of HLA-A1/blank constitution (46%). Deviations from the overall mean anti-VCA titer (GMT 131.5) were found in seropositive subjects with blood group 0 (GMT 153.3) and tissue antigens HLA-A3 (GMT 150.8), HLA-B7 (GMT 152.1), HA-Bw15 (GMT 97.0), and HLA-B27 (GMT 86.4). Separate reanalysis of the data for male and female subjects verified the association of blood group 0 with elevated and HLA-B27 with reduced mean levels of anti-VCA antibody. |
| Databáze: | OpenAIRE |
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