Bioactive effects of strontium loading on micro/nano surface Ti6Al4V components fabricated by selective laser melting
| Autor: | Yu Shimizu, Kazutaka Masamoto, Shuichi Matsuda, Toshiyuki Kawai, Kazuaki Morizane, Takayoshi Shimizu, Bungo Otsuki, Tomotoshi Kawata, Kitagaki Hisashi, Shigeo Mori, Yaichiro Okuzu, Seiji Yamaguchi, Shunsuke Fujibayashi, Koji Goto |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Surface Properties Simulated body fluid chemistry.chemical_element Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Osseointegration Apatite Cell Line Biomaterials Mice Coated Materials Biocompatible Materials Testing Alloys Animals Humans Selective laser melting Titanium Strontium Lasers Titanium alloy 021001 nanoscience & nanotechnology Nanostructures 0104 chemical sciences chemistry Chemical engineering Mechanics of Materials visual_art visual_art.visual_art_medium Surface modification 0210 nano-technology |
| Zdroj: | Materials Science and Engineering: C. 109:110519 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2019.110519 |
| Popis: | Selective laser melting (SLM) titanium alloys require surface modification to achieve early bone-bonding. This study investigated the effects of solution and heat treatment to induce the sustained release of strontium (Sr) ions from SLM Ti6Al4V implants (Sr-S64). The results were compared with a control group comprising an untreated surface [SLM pure titanium (STi) and SLM Ti6Al4V (S64)] and a treated surface to induce the release of calcium (Ca) ions from SLM Ti6Al4V (Ca-S64). The surface-treated materials showed homogenous nanoscale network formation on the original micro-topographical surface and formed bone-like apatite on the surface in a simulated body fluid within 3 days. In vitro evaluation using MC3T3-E1 cells showed that the cells were viable on Sr-S64 surface, and Sr-S64 enhanced cell adhesion-related and osteogenic differentiation-related genes expression. In vivo rabbit tibia model, Sr-S64 provided significantly greater bone-bonding strength and bone-implant contact area than those in controls (STi and S64) in the early phase (2–4 weeks) after implantation; however, there was no statistical difference between Ca-S64 and controls. In conclusion, Sr solution and heat treatment was a safe and effective method to enhance early bone-bonding ability of S-64 by improving the surface characteristics and sustained delivery for Sr. |
| Databáze: | OpenAIRE |
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