Systemic lupus erythematosus in the intensive care unit: a systematic review
| Autor: | Linda M Gallego, Ingrid Ruiz-Ordoñez, Maria A Guerra, Cindy-Natalia Gallego, Juan D Bolaños, Maria Elena Ochoa, Cristian C. Aragón, Marcela Granados, Ana Suárez-Avellaneda, Jhon H Quintana, Gabriel J. Tobón |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Multiple Organ Failure medicine.medical_treatment Infections law.invention Disease activity 03 medical and health sciences 0302 clinical medicine Rheumatology immune system diseases law Vasoactive Humans Lupus Erythematosus Systemic Medicine Hospital Mortality 030212 general & internal medicine skin and connective tissue diseases Intensive care medicine APACHE 030203 arthritis & rheumatology Autoimmune disease Mechanical ventilation business.industry Mortality rate Prognosis medicine.disease Intensive care unit Intensive Care Units Respiratory failure Health evaluation Respiratory Insufficiency business |
| Zdroj: | Lupus. 29:1364-1376 |
| ISSN: | 1477-0962 0961-2033 |
| DOI: | 10.1177/0961203320941941 |
| Popis: | Systemic lupus erythematosus (SLE) is an autoimmune disease with heterogeneous pathophysiologic mechanisms and diverse clinical manifestations. SLE is a frequent cause of intensive care unit (ICU) admissions. Multiple studies with controversial findings on the causes, evolution and outcomes of ICU-admitted patients with SLE have been published. The aim of this paper is to review the literature reporting the clinical characteristics and outcomes, such as mortality and associated factors, in such patients. Among the main causes of ICU admissions are SLE disease activity, respiratory failure, multi-organ failure and infections. The main factors associated with mortality are a high Acute Physiology and Chronic Health Evaluation (APACHE) score, the need for mechanical ventilation, and vasoactive and inotropic agent use. Reported mortality rates are 18.4%–78.5%. Therefore, it is important to evaluate SLE disease severity for optimizing clinical management and patient outcomes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |