Galectin-3 expression in prostate cancer and benign prostate tissues: correlation with biochemical recurrence
| Autor: | Christian Schwentner, Soum D. Lokeshwar, Mario W. Kramer, Judith Knapp, Arnulf Stenzl, Ulrich Vogel, Jörg Hennenlotter, Axel S. Merseburger |
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| Rok vydání: | 2012 |
| Předmět: |
Male
PCA3 Biochemical recurrence medicine.medical_specialty Pathology Galectin 3 Urology medicine.medical_treatment Prostate cancer medicine Humans Tissue microarray business.industry Prostatectomy Prostate Prostatic Neoplasms Middle Aged Prognosis medicine.disease Immunohistochemistry Staining Tissue Array Analysis Tumor progression Neoplasm Recurrence Local business |
| Zdroj: | World Journal of Urology. 31:351-358 |
| ISSN: | 1433-8726 0724-4983 |
| DOI: | 10.1007/s00345-012-0925-y |
| Popis: | Galactin-3 is a cell adhesion molecule involved in tumor progression. Our aim was to examine Gal-3 expression in tumor, benign tissue adjacent to the tumor (adjacent-benign) and benign prostate specimens and correlated it with biochemical recurrence. Tissue microarrays were prepared from 83 tumor, 78 adjacent-benign and 75 benign tissues obtained from 83 patients undergoing prostatectomy for clinically localized prostate cancer. Tissues were stained using a Gal-3 antibody and immunohistochemistry. The staining was graded between 0 and 300 depending upon staining intensity and the area of staining. In 37 patients on whom there was follow-up (Mean: 57.8 months; Median: 68 months), staining intensity was correlated with biochemical recurrence. Gal-3 showed both nuclear and cytoplasmic localization in benign, adjacent-benign and tumor tissues. Median Gal-3 staining scores significantly decreased from benign (192.5) to adjacent-benign (148.8 p = 0.007) and to tumor (108.8; p |
| Databáze: | OpenAIRE |
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