Surgical management for early-stage bilateral breast cancer patients in China
| Autor: | Jia Jian Chen, Zhi Min Shao, Nai Si Huang, Yu Long Tan, Chen Lian Quan, Jiong Wu, Guang Yu Liu, Jing Yan Xue |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty China medicine.medical_treatment Mammaplasty lcsh:Medicine Breast Neoplasms Breast cancer Surgical oncology Medicine Humans Stage (cooking) lcsh:Science skin and connective tissue diseases Mastectomy Aged Neoplasm Staging Aged 80 and over Multidisciplinary business.industry General surgery lcsh:R Middle Aged medicine.disease Bilateral breast cancer Surgery lcsh:Q Female sense organs business Breast reconstruction Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 10, Iss 4, p e0122692 (2015) |
| ISSN: | 1932-6203 |
| Popis: | BACKGROUND:The aim of this study was to investigate the current surgical management strategy for bilateral breast cancer (BBC) patients and to assess the changes in this strategy in China. METHODS:This is a retrospective review of all patients with early-stage BBC who underwent surgical treatment at the Fudan University Shanghai Cancer Center between June 2007 and June 2014. RESULTS:A total of 15,337 patients with primary breast cancer were identified. Of these patients, 218 (1.5%) suffered from synchronous bilateral breast cancer (sBBC), and 296 (2.0%) suffered from metachronous bilateral breast cancer (mBBC). Patients with a lobular carcinoma component, those with estrogen receptor-positive cancer, and those with an accompanying sclerosing adenosis in the affected breast tended to develop BBC. The rates of bilateral mastectomy, breast conserving therapy, reconstruction, and combined surgeries were 86.2%, 6.4%, 3.7%, and 3.7%, respectively, for patients with sBBC and 81.1%, 4.4%, 3.0%, and 11.5%, respectively, for patients with mBBC. The interval between bilateral cancers, age at first diagnosis of breast cancer, histopathological type, and stage have significant impacts on the choice of surgery for patients with BBC. CONCLUSIONS:Bilateral mastectomy was the dominant surgical management for patients with BBC in China, despite the increased application of breast reconstruction surgery observed in recent years. Bilateral prosthetic breast reconstruction was the ideal choice for patients with sBBC. Chinese surgeons should take responsibility for patient education and inform their patients about their surgical options. |
| Databáze: | OpenAIRE |
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