Relationships between HIV disease history and blood HIV-1 DNA load in perinatally infected adolescents and young adults: The ANRS-EP38-IMMIP Study
| Autor: | Josiane Warszawski, Véronique Avettand-Fenoel, Stéphane Blanche, Jérôme Le Chenadec, Jean-Paul Viard, Naima Bouallag, Yves Rivière, Florence Buseyne, Daniel Scott-Algara, Christine Rouzioux, Catherine Dollfus, Yassine Benmebarek |
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| Přispěvatelé: | Laboratoire de Virologie [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'immuno-hématologie pédiatrique [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Régulation des Infections Rétrovirales, Institut Pasteur [Paris], Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau], CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Paris Descartes - Paris 5 (UPD5), Centre de Diagnostic et de Thérapeutique, Hôpital de l’Hôtel-Dieu [Paris], Immunopathologie Virale, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11), Infection à VIH, réservoirs, diversité génétique et résistance aux antirétroviraux (ARV) (EA 7327), Epidémiologie et Physiopathologie des Virus Oncogènes (EPVO (UMR_3569 / U-Pasteur_3)), Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), ANRSFondation AREVA, ANRS-EP38-IMMIP, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris] (IP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Centre de recherche en épidémiologie et santé des populations ( CESP ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service d'Hématologie et Oncologie pédiatriques, Hôpital Trousseau [Paris], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Trousseau [APHP], Université Paris Descartes - Paris 5 ( UPD5 ), Assistance publique - Hôpitaux de Paris (AP-HP), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique ( CNRS ), Université Paris-Sud - Paris 11 ( UP11 ), Infection à VIH, réservoirs, diversité génétique et résistance aux antirétroviraux (ARV) ( EA 7327 ), Epidémiologie et Physiopathologie des Virus Oncogènes, Buseyne, Florence |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
MESH: CD4 Lymphocyte Count MESH : Pregnancy Complications Infectious/virology HIV Infections MESH : Viral Load Disease law.invention MESH: Pregnancy Complications Infectious/virology 0302 clinical medicine MESH: Pregnancy Pregnancy [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases cell-associated HIV DNA MESH: HIV Infections/blood Young adult HIV perinatal infection 0303 health sciences MESH: DNA Viral/blood MESH: RNA Viral/blood virus diseases MESH: HIV Infections/transmission MESH: Follow-Up Studies 3. Good health [ SDV.MHEP.MI ] Life Sciences [q-bio]/Human health and pathology/Infectious diseases [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology MESH: Young Adult [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Disease Progression MESH: Disease Progression MESH : Viremia Viral load MESH : Young Adult MESH : Cohort Studies Viremia MESH : HIV Infections/blood MESH: HIV-1/isolation & purification [ SDV.MP.VIR ] Life Sciences [q-bio]/Microbiology and Parasitology/Virology 03 medical and health sciences MESH : Adolescent Humans MESH : HIV Infections/transmission MESH: Adolescent MESH: Humans MESH : Humans MESH : Follow-Up Studies MESH : Disease Progression medicine.disease MESH : Antiretroviral Therapy Highly Active Virology Infectious Disease Transmission Vertical MESH : Pregnancy Immunology DNA Viral HIV-1 MESH: Female [ SDV.MHEP.PED ] Life Sciences [q-bio]/Human health and pathology/Pediatrics [ SDV.IMM.IA ] Life Sciences [q-bio]/Immunology/Adaptive immunology MESH: Antiretroviral Therapy Highly Active Cohort Studies law Antiretroviral Therapy Highly Active Immunology and Allergy MESH : RNA Viral/blood MESH : Female 030212 general & internal medicine adolescents Pregnancy Complications Infectious MESH : Infectious Disease Transmission Vertical MESH: Cohort Studies Polymerase chain reaction [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology MESH: Real-Time Polymerase Chain Reaction MESH: HIV Infections/drug therapy MESH: Infant Newborn MESH : HIV-1/genetics Viral Load MESH: Infectious Disease Transmission Vertical Infectious Diseases Real-time polymerase chain reaction [SDV.IMM.IA] Life Sciences [q-bio]/Immunology/Adaptive immunology Human Immunodeficiency Virus DNA [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases RNA Viral Female MESH: Viral Load MESH : DNA Viral/blood Adolescent MESH : HIV Infections/drug therapy MESH : Male MESH : Real-Time Polymerase Chain Reaction Biology Real-Time Polymerase Chain Reaction MESH : Infant Newborn Peripheral blood mononuclear cell Young Adult [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics cumulative viremia medicine MESH : CD4 Lymphocyte Count MESH: Viremia 030304 developmental biology [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics MESH: HIV-1/genetics Infant Newborn MESH: Male CD4 Lymphocyte Count MESH : HIV-1/isolation & purification MESH : HIV-1/drug effects MESH: HIV-1/drug effects Follow-Up Studies |
| Zdroj: | Journal of Infectious Diseases Journal of Infectious Diseases, Oxford University Press (OUP), 2012, 205 (10), pp.1520-1528. ⟨10.1093/infdis/jis233⟩ Journal of Infectious Diseases, 2012, 205 (10), pp.1520-1528. ⟨10.1093/infdis/jis233⟩ Journal of Infectious Diseases, Oxford University Press (OUP), 2012, 205 (10), pp.1520-1528. 〈10.1093/infdis/jis233〉 |
| ISSN: | 0022-1899 1537-6613 |
| DOI: | 10.1093/infdis/jis233⟩ |
| Popis: | Background. Our aim was to study the impact of lifelong human immunodeficiency virus (HIV) disease history on the current immune and virological status of perinatally infected patients reaching adulthood. We evaluated blood cell–associated HIV DNA load as an indicator of cell-associated HIV reservoirs and an independent predictor of disease progression. Methods. The ANRS-EP38-IMMIP Study included 93 patients aged 15–24 years who were infected with HIV during the perinatal period. HIV DNA load was quantified by real-time polymerase chain reaction. Results. Eighty-five percent of patients were receiving highly active antiretroviral therapy (HAART), and HIV RNAwas undetectableintheplasmaof75%ofthesepatients.ThemedianHIV DNAloadwas 2.84(interquartilerange, 2.51–3.16) log10 copies per 10 6 peripheral blood mononuclear cells. In patients with viral suppression, HIV DNA load was independently associated with cumulative HIV RNA viremia over the last 5 years. HIV DNA load was negatively correlated with CD4 cell count in patients with active replication but not in those with undetectable HIV RNA. Conclusions. In perinatally infected youths who are successfully treated, sustained viral suppression is associated with a low HIV DNA load. The absence of association between current HIV DNA load and CD4 cell counts suggests that the unique physiological characteristics of pediatric infection persist after adolescence. Clinical Trials Registration. NCT01055873. |
| Databáze: | OpenAIRE |
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