Increased oxidative stress in the mitochondria isolated from lymphocytes of bipolar disorder patients during depressive episodes
| Autor: | Cenita Borges, Emilio L. Streck, Milena Carvalho-Silva, Amanda V. Steckert, Roger B. Varela, Gustavo Feier, Kelen Cechinel-Recco, Daniela V. Bavaresco, Lara M. Gomes, João Quevedo, Samira S. Valvassori |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Thiobarbituric acid Mitochondrion medicine.disease_cause Thiobarbituric Acid Reactive Substances Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Superoxides Internal medicine mental disorders medicine TBARS Humans Submitochondrial particle Bipolar disorder Lymphocytes Biological Psychiatry biology Chemistry Superoxide Depression Superoxide Dismutase Middle Aged medicine.disease Cyclothymic Disorder 030227 psychiatry Mitochondria Psychiatry and Mental health Oxidative Stress Endocrinology biology.protein Female Oxidation-Reduction 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Psychiatry research. 264 |
| ISSN: | 1872-7123 |
| Popis: | The present study aims to investigate the oxidative stress parameters in isolated mitochondria, as well as looking at mitochondrial complex activity in patients with Bipolar Disorder (BD) during depressive or euthymic episodes. This study evaluated the levels of mitochondrial complex (I, II, II-III and IV) activity in lymphocytes from BD patients. We evaluated the following oxidative stress parameters: superoxide, thiobarbituric acid reactive species (TBARS) and carbonyl levels in submitochondrial particles of lymphocytes from bipolar patients. 51 bipolar patients were recruited into this study: 34 in the euthymic phase, and 17 in the depressive phase. Our results indicated that the depressive phase could increase the levels of mitochondrial superoxide, carbonyl and TBARS, and superoxide dismutase, and could decrease the levels of mitochondrial complex II activity in the lymphocytes of bipolar patients. It was also observed that there was a negative correlation between the Hamilton Depression Rating Scale (HDRS) and complex II activity in the lymphocytes of depressive bipolar patients. In addition, there was a positive correlation between HDRS and superoxide, superoxide dismutase, TBARS and carbonyl. Additionally, there was a negative correlation between complex II activity and oxidative stress parameters. In conclusion, our results suggest that mitochondrial oxidative stress and mitochondrial complex II dysfunction play important roles in the depressive phase of BD. |
| Databáze: | OpenAIRE |
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