Use of Hemadsorption in a Case of Pediatric Toxic Shock Syndrome
Autor: | László Ujhelyi, Edit Szikszay, János Kappelmayer, Tamás Szabó, József Balla, Krisztina Bari, Andrea Berkes, György Balla, Adrienne Kerényi |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
medicine.medical_specialty
medicine.medical_treatment Hemodynamics Case Report Disease 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine Systemic inflammation Klinikai orvostudományok 03 medical and health sciences 0302 clinical medicine Medicine Renal replacement therapy Intensive care medicine business.industry lcsh:Medical emergencies. Critical care. Intensive care. First aid Toxic shock syndrome 030208 emergency & critical care medicine Orvostudományok lcsh:RC86-88.9 Immune modulation medicine.disease Cytokine Hemadsorption Immunology medicine.symptom business |
Zdroj: | Case Reports in Critical Care, Vol 2017 (2017) Case Reports in Critical Care |
ISSN: | 2090-6439 2090-6420 |
Popis: | Background. Toxic shock syndrome is a potentially fatal toxin-mediated disease. The role of toxins in this clinical entity made us hypothesize that extracorporeal blood purification with CytoSorb® could play a beneficial role in the clinical management of toxic shock syndrome. This case report describes the successful treatment of toxic shock syndrome using a combination of renal replacement therapy and hemadsorption in a pediatric patient. Case Presentation. A 5-year-old girl with Down’s syndrome presented with an inflamed area surrounding an insect bite, signs of systemic inflammation, and multiple organ failure. As previous attempts of immune modulation therapy were unsuccessful, renal replacement therapy was supplemented by the cytokine absorber CytoSorb. Treatment using this combination was associated with a rapid and significant stabilization in the hemodynamic situation and a decrease in inflammatory mediators within hours after the initiation of therapy. The application of CytoSorb therapy was simple and safe. Conclusion. The use of extracorporeal blood purification with CytoSorb proved potentially beneficial by removing toxins and inflammatory mediators in this case and could therefore play a role in the clinical management of toxic shock syndrome. Whether CytoSorb has the potential to even positively influence mortality in patients with toxic shock syndrome still needs to be confirmed. |
Databáze: | OpenAIRE |
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