Usefulness of triglycerides-to-high-density lipoprotein cholesterol ratio for predicting the first coronary event in men
| Autor: | María Bes, José A. Casasnovas, Montserrat León, Alberto Cordero, Martín Laclaustra, Isaac Pascual, Fernando Civeira, Eduardo Alegría, Beatriz Ordoñez, Emilio Luengo, Miguel Pocovi, José Moreno, Alberto Grima, Eva Andrés |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Myocardial Ischemia Risk Assessment Body Mass Index Angina Electrocardiography Predictive Value of Tests Internal medicine medicine Diabetes Mellitus Humans Myocardial infarction Angina Unstable Obesity Triglycerides Aged Unstable angina business.industry Case-control study Odds ratio Middle Aged medicine.disease Confidence interval Lipoproteins LDL Case-Control Studies Hypertension Multivariate Analysis Cardiology Metabolic syndrome Cardiology and Cardiovascular Medicine business Lipoproteins HDL Body mass index Biomarkers |
| Zdroj: | The American journal of cardiology. 104(10) |
| ISSN: | 1879-1913 |
| Popis: | Overweight and obesity potentiate the development of cardiovascular risk factors but many doubts have arisen recently regarding their role in coronary events. We evaluated the predictive value of a surrogate maker of insulin resistance, the ratio of triglyceride (TG) to high-density lipoprotein (HDL), for the incidence of a first coronary event in men workers according to body mass index (BMI). We designed a case-control study of active subjects collected from a single factory through their annual health examination and medical reports. Case subjects included those with myocardial infarction, unstable angina pectoris, or subclinical myocardial ischemia detected through electrocardiographic abnormalities. The sample was constituted by 208 case and 2,080 control subjects (mean age 49.9 years, 49.6 to 50.2). General characteristics of case and control subjects were well matched. The TG/HDL ratio was significantly higher in case subjects compared to controls. Stratification of the sample revealed an increasing prevalence of case subjects and mean TG/HDL in each category of BMI. Multivariable analysis, adjusted by smoking, demonstrated that TG/HDL increased 50% the risk of a first coronary event (odds ratio [OR] 1.47, 95% confidence interval [CI] 1.26 to 1.71), whereas low-density lipoprotein cholesterol values indicated a more moderate increased risk (OR 1.01, 95% CI 1.005 to 1.012); metabolic syndrome (OR 1.76, 95% CI 0.94 to 3.30) and hypertension (OR 1.50, 95% CI 0.81 to 2.79) did not reach statistical significance. The TG/HDL ratio was associated with a first coronary event in all categories of BMI. In conclusion, the TG/HDL ratio has a high predictive value of a first coronary event regardless of BMI. |
| Databáze: | OpenAIRE |
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