| Autor: |
Naohiro Iwata, Daisuke Kobayashi, Takehiro Kawashiri, Toshio Kubota, Kotomi Kawano, Yuki Yamamuro, Anna Miyagi, Yuya Deguchi, Takeshi Chijimatsu, Takao Shimazoe |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Biologicalpharmaceutical bulletin. 45(6) |
| ISSN: |
1347-5215 |
| Popis: |
Nutmeg, a dried seed kernel of a tall evergreen Myristicaceae tree, is widely used as a spice and herbal medicine and is known to have antidepressant-like effects. This study evaluates the mechanisms underlying this antidepressant-like effect and safety of nutmeg n-hexane extract (NNE) in mice. Tail suspension and open field tests showed that NNE (10 mg/kg, per OS (p.o.)) significantly decreased the immobility time of mice without effecting their spontaneous locomotor activity. The reduction of immobility time of mice elicited by NNE was significantly inhibited by ketanserin (5-hydroxytryptamine (5-HT) |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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