Hydrophobic polymers for orodispersible films: a quality by design approach
| Autor: | Ana Filipa Borges, Branca M. A. Silva, Jorge F. J. Coelho, Cláudia Silva, Sérgio Simões |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Polymers Chemistry Pharmaceutical Pharmaceutical Science 02 engineering and technology Methacrylate 030226 pharmacology & pharmacy Excipients 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Plasticizers Shellac Copolymer Composite material Solubility chemistry.chemical_classification Polyvinyl acetate Plasticizer Water Polymer 021001 nanoscience & nanotechnology chemistry visual_art visual_art.visual_art_medium Polyvinyls 0210 nano-technology Critical quality attributes Hydrophobic and Hydrophilic Interactions |
| Zdroj: | Expert opinion on drug delivery. 13(10) |
| ISSN: | 1744-7593 |
| Popis: | To develop orodispersible films (ODF) based on hydrophobic polymers with higher stability to ordinary environmental humidity conditions without compromising their fast disintegration time.A quality by design approach was applied to screen three different formulations each one based on a different hydrophobic polymer: polyvinyl acetate, methacrylate-based copolymer and shellac. The screening formulations were characterized regarding their mechanical properties, residual water content, disintegration time and appearance, in order to find a suitable ODF formulation according to established critical quality attributes. The selected critical process parameters for the selection of appropriate ODF formulations were the percentage of the different excipients and the plasticizer type.Three hydrophobic-based matrices with fast disintegration were developed. These were generically composed by a hydrophobic polymer, a stabilizer, a disintegrant and a plasticizer. It verified that the common components within the three different formulations behave differently depending on the system/chemical environment that they were included.It was shown that it is possible to develop oral films based on hydrophobic polymers with fast disintegration time, good texture and appearance, breaking a paradigm of the ODF research field. |
| Databáze: | OpenAIRE |
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