Bacterial biofilm formation on indwelling urethral catheters
| Autor: | Brian V. Jones, Emma L. Denham, Scarlet Milo, J.M. Sutton, Lucy J. Bock, Wendy M. Macfarlane, Jonathan Nzakizwanayo, H. Pelling |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
medicine.medical_specialty Urethral Catheters Urinary Catheters Phage Therapy/methods 01 natural sciences Urinary Catheterization/adverse effects Applied Microbiology and Biotechnology Care setting catheters 03 medical and health sciences Catheters Indwelling 010608 biotechnology Proteus mirabilis/growth & development Medicine Humans Biofilms/growth & development Phage Therapy Intensive care medicine Proteus mirabilis 0303 health sciences Urinary tract infection biology Urinary Tract Infections/microbiology 030306 microbiology business.industry Proteus Infections Catheter blockage Biofilm biology.organism_classification Urease 3. Good health Catheter Urethra medicine.anatomical_structure Catheters Indwelling/microbiology Biofilms Urinary Catheters/microbiology Urinary Tract Infections Urease/therapeutic use biofilms Urinary Catheterization business |
| Zdroj: | Pelling, H, Nzakizwanayo, J, Milo, S, Denham, E L, MacFarlane, W M, Bock, L J, Sutton, J M & Jones, B V 2019, ' Bacterial biofilm formation on indwelling urethral catheters ', Letters in Applied Microbiology, vol. 68, no. 4, pp. 277-293 . https://doi.org/10.1111/lam.13144 |
| DOI: | 10.1111/lam.13144 |
| Popis: | Urethral catheters are the most commonly deployed medical devices and used to manage a wide range of conditions in both hospital and community care settings. The use of long-term catheterization, where the catheter remains in place for a period >28 days remains common, and the care of these patients is often undermined by the acquisition of infections and formation of biofilms on catheter surfaces. Particular problems arise from colonization with urease-producing species such as Proteus mirabilis, which form unusual crystalline biofilms that encrust catheter surfaces and block urine flow. Encrustation and blockage often lead to a range of serious clinical complications and emergency hospital referrals in long-term catheterized patients. Here we review current understanding of bacterial biofilm formation on urethral catheters, with a focus on crystalline biofilm formation by P. mirabilis, as well as approaches that may be used to control biofilm formation on these devices. Significance and Impact of the Study: Urinary catheters are the most commonly used medical devices in many healthcare systems, but their use predisposes to infection and provide ideal conditions for bacterial biofilm formation. Patients managed by long-term urethral catheterization are particularly vulnerable to biofilm-related infections, with crystalline biofilm formation by urease producing species frequently leading to catheter blockage and other serious clinical complications. This review considers current knowledge regarding biofilm formation on urethral catheters, and possible strategies for their control. |
| Databáze: | OpenAIRE |
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