Chitosan-coated electrospun nanofibers with antibacterial activity
| Autor: | Christine Jérôme, Christine C. Dupont-Gillain, Christophe Detrembleur, Michel J. Genet, Pierre Sibret, Florence Croisier |
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| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Materials science Carboxylic acid Biomedical Engineering General Chemistry General Medicine Electrospinning Chitosan chemistry.chemical_compound chemistry Chemical engineering Nanofiber Polymer chemistry Copolymer General Materials Science Fiber Antibacterial activity Layer (electronics) |
| Zdroj: | Journal of materials chemistry. B. 3(17) |
| ISSN: | 2050-7518 |
| Popis: | Charged nanofibers were prepared by electrospinning (ESP) poly(e-caprolactone) with a copolymer bearing carboxylic acid functions. The presence of these functions allowed exposing some negative charges on the fiber surface, by dipping the fibers in a phosphate buffer. A layer of chitosan, a polycation in acidic medium, was then deposited on the nanofiber surface, thanks to electrostatic attraction. Fibers were characterized at each step of the process and the influence of the copolymer architecture on chitosan deposition was discussed. The antibacterial activity of the resulting fibers was finally assessed. |
| Databáze: | OpenAIRE |
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