Extended spectrum beta-lactamases (ESBL) in Escherichia coli and Klebsiella pneumoniae: trends in the hospital and community settings
| Autor: | Khalid M. Bindayna, Giuseppe A. Botta, Abiola Senok, Husam S. Khanfar |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Klebsiella Imipenem Klebsiella pneumoniae medicine.medical_treatment polycyclic compounds Medicine Child Escherichia coli Infections Aged 80 and over Cross Infection biology General Medicine Middle Aged Hospitals Anti-Bacterial Agents Community-Acquired Infections Ciprofloxacin Infectious Diseases Amikacin Child Preschool Female Gentamicin medicine.drug Adult Adolescent Saudi Arabia Microbial Sensitivity Tests beta-Lactams Microbiology beta-Lactam Resistance beta-Lactamases Young Adult Virology Escherichia coli Humans Aged business.industry Infant Newborn Infant biochemical phenomena metabolism and nutrition Amoxicillin bacterial infections and mycoses biology.organism_classification Klebsiella Infections Beta-lactamase Parasitology business |
| Zdroj: | The Journal of Infection in Developing Countries. 3 |
| ISSN: | 1972-2680 2036-6590 |
| DOI: | 10.3855/jidc.127 |
| Popis: | To assess the prevalence of extended spectrum beta-lactamase (ESBL) producing Escherichia coli and Klebsiella strains in nosocomial and community-acquired infections.The study was conducted at a centralized microbiology laboratory in the Eastern Province of Saudi Arabia. Laboratory records (January 2004 - December 2005) were assessed. Associated resistance to a panel of antibiotics was determined.A total of 6,750 Gram-negative organisms were assessed for ESBL-phenotype. ESBL was detected in 6% (409/6,750) of isolates, the majority of which were E. coli (83%). ESBL producers were significantly higher among isolates from in-patients 15.4% (143/927) versus out-patients (4.5%; 266/5,823); p0.05. Old age (older than 60 years) represented a significant risk for having an ESBL-producing pathogen. Urine was the major source of ESBL isolates in in-patients (46.1%) and out-patients (74.4%). The proportion of urinary E. coli isolates which were ESBL producers was significantly higher among in-patients (53/506; 10.4%) compared to out-patients (182/4,074; 4.4%); p0.05. Old age (older than 60 years) represented a significant risk for having an ESBL-producing pathogen. Urine was the major source of ESBL isolates in in-patients (46.1%) and out-patients (74.4%). The proportion of urinary E. coli isolates which were ESBL producers was significantly higher among in-patients (53/506; 10.4%) compared to out-patients (182/4,074; 4.4%); p0.05. Among in-patients, 60% of the ESBL associated infections were nosocomial. All were sensitive to imipenem but high levels of resistance to gentamicin, amikacin, amoxicillin-clavulanic acid and ciprofloxacin was shown.The findings document evidence of the spread of multiresistant ESBL-producers into the community. This has significant implications for patient management, and indicates the need for increased surveillance and molecular characterization of these isolates. |
| Databáze: | OpenAIRE |
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