Aldosterone dysregulation predicts the risk of mortality and rehospitalization in heart failure with a preserved ejection fraction
| Autor: | Yangkai Fan, Yixin Zhang, Xin Tan, Qiqi Sun, Jie Du, Bingbing Ke, Yuan Wang, Lu Ren, Lixin Jia, Tong Liu, Fengjuan Li |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Patient Readmission General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Interquartile range Internal medicine Natriuretic Peptide Brain medicine Risk of mortality Natriuretic peptide Humans Aldosterone Aged Retrospective Studies General Environmental Science Heart Failure Ejection fraction Ventricular Remodeling business.industry Hazard ratio Stroke Volume Odds ratio Middle Aged medicine.disease Hospitalization chemistry Heart failure Cardiology Female General Agricultural and Biological Sciences business |
| Zdroj: | Science China Life Sciences. 65:631-642 |
| ISSN: | 1869-1889 1674-7305 |
| Popis: | Serum aldosterone is associated with cardiac remodeling, which contributes to morbidity and mortality in heart failure (HF); however, the prognostic value of aldosterone in HF with a preserved ejection fraction (HFpEF) is unclear. We used liquid chromatography-tandem mass spectrometry to quantify serum aldosterone in 873 patients with HFpEF in a Registry Study of Biomarkers for HF. The retrospective study was conducted at Beijing Anzhen Hospital from May 2017 to October 2019. The primary endpoint was a composite of all-cause mortality and rehospitalization for HF. Aldosterone concentrations in patients with and without events were 124.22 pmol L-1 (interquartile range (IQR): 48.62-256.20) and 96.33 pmolL-1 (IQR: 37.33-215.76), respectively (P=0.023). Aldosterone independently predicted all-cause mortality (adjusted hazard ratio (aHR), 1.55; 95% confidence interval (95%CI), 1.06-2.27; P=0.024) and the primary endpoint (aHR, 1.43; 95%CI, 1.11-1.85; P=0.006). Patients with high aldosterone concentrations were at higher risk of concentric remodeling (adjusted odds ratio (aOR), 1.45; 95% CI, 1.03-2.04; P=0.034). Patients with high aldosterone and B-type natriuretic peptide concentrations were at a higher risk of the primary endpoint (hazard ratio (HR), 1.85; 95%CI, 1.29-2.66; P=0.001). We conclude that elevated aldosterone is associated with a risk of rehospitalization with HF and all-cause mortality in patients with HFpEF. |
| Databáze: | OpenAIRE |
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