Simultaneous determination of hydrochlorothiazide and several angiotensin-II-receptor antagonists by capillary electrophoresis
| Autor: | W. Van den Bossche, Sandra Hillaert |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Losartan Potassium
Receptors Angiotensin Chromatography Chemistry Angiotensin II Clinical Biochemistry Electrophoresis Capillary Reproducibility of Results Pharmaceutical Science Micellar electrokinetic chromatography Analytical Chemistry Angiotensin Receptor Antagonists Hydrochlorothiazide Losartan Capillary electrophoresis Irbesartan Drug Discovery medicine Eprosartan Mesylate Antihypertensive Agents Spectroscopy Chromatography Micellar Electrokinetic Capillary medicine.drug |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 31:329-339 |
| ISSN: | 0731-7085 |
| DOI: | 10.1016/s0731-7085(02)00643-x |
| Popis: | We have investigated the capability of the capillary zone electrophoretic (CZE) and micellar electrokinetic capillary chromatographic (MEKC) methods to simultaneously separate hydrochlorothiazide and six angiotensin-II-receptor antagonists (ARA-IIs): candesartan, eprosartan mesylate, irbesartan, losartan potassium, telmisartan, and valsartan. The CZE and MEKC methods are suitable for the qualitative and quantitative determination of combined HCT/ARA-IIs in pharmaceutical formulations. Depending on the ARA-II, at least one of the two methods can be used for each combination. The two methods have been validated in terms of their linearity of response, reproducibility, and accuracy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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