Are basic auditory processes involved in source-monitoring deficits in patients with schizophrenia?
| Autor: | Frédéric Haesebaert, David I. Leitman, Jerome Brunelin, Marine Mondino, Marie-Françoise Suaud-Chagny, Thierry d'Amato, Clément Dondé, Daniel C. Javitt |
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| Přispěvatelé: | Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier le Vinatier [Bron], Columbia University Medical Center (CUMC), Columbia University [New York], CCSD, Accord Elsevier |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty [SDV]Life Sciences [q-bio] Audiology Young Adult 03 medical and health sciences 0302 clinical medicine Tone-matching Source-monitoring medicine Humans Cognitive Dysfunction In patient Psychoacoustics Auditory function 10. No inequality Biological Psychiatry Positive and Negative Syndrome Scale business.industry Auditory Perceptual Disorders Symptom severity Cognition Middle Aged medicine.disease 030227 psychiatry [SDV] Life Sciences [q-bio] Psychiatry and Mental health Schizophrenia Imagination Speech Perception Female Basic auditory processing Positive symptoms business 030217 neurology & neurosurgery |
| Zdroj: | Schizophrenia Research Schizophrenia Research, Elsevier, 2019, 210, pp.135-142. ⟨10.1016/j.schres.2019.05.034⟩ Schizophrenia Research, 2019, 210, pp.135-142. ⟨10.1016/j.schres.2019.05.034⟩ |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2019.05.034⟩ |
| Popis: | International audience; Patients with schizophrenia (SZ) display deficits in both basic non-verbal auditory processing and source-monitoring of speech. To date, the contributions of basic auditory deficits to higher-order cognitive impairments, such as source-monitoring, and to clinical symptoms have yet to be elucidated. The aim of this study was to investigate the deficits and relationships between basic auditory functions, source-monitoring performances, and clinical symptom severity in SZ. Auditory processing of 4 psychoacoustic features (pitch, intensity, amplitude, length) and 2 types of source-monitoring (internal and reality monitoring) performances were assessed in 29 SZ and 29 healthy controls. Clinical symptoms were evaluated in patients with the Positive And Negative Syndrome Scale. Compared to the controls, SZ individuals in showed significant reductions in both global basic auditory processing (p < .0005, d = 1.16) and source-monitoring (p < .0005, d = 1.24) abilities. Both deficits correlated significantly in patients and across groups (all p < .05). Pitch processing skills were negatively correlated with positive symptom severity (r = -0.4, p < .05). A step-wise regression analysis showed that pitch discrimination was a significant predictor of source-monitoring performance. These results suggest that cognitive mechanisms associated with the discrimination of basic auditory features are most compromised in patients with source-monitoring disability. Basic auditory processing may index pathophysiological processes that are critical for optimal source-monitoring in schizophrenia and that are involved in positive symptoms. |
| Databáze: | OpenAIRE |
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