Radiological Assessment and Outcome of Local Disease Progression after Neoadjuvant Chemotherapy in Children and Adolescents with Localized Osteosarcoma

Autor:	Marilyn Ranson, Eleanor Hendershot, Jennifer Stimec, Anne L. Ryan, Paul Gibson, Abha A. Gupta, Sevan Hopyan, Adriana Fonseca
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	medicine.medical_specialty lcsh:Medicine Article 03 medical and health sciences 0302 clinical medicine Cohen's kappa osteosarcoma radiological progression Medicine 030222 orthopedics medicine.diagnostic_test business.industry lcsh:R Magnetic resonance imaging General Medicine medicine.disease Primary tumor Log-rank test Clinical trial Response Evaluation Criteria in Solid Tumors 030220 oncology & carcinogenesis Radiological weapon Radiology business Progressive disease MRI
Zdroj:	Journal of Clinical Medicine Volume 9 Issue 12 Journal of Clinical Medicine, Vol 9, Iss 4070, p 4070 (2020)
ISSN:	2077-0383
Popis:	Objective: We examined the interobserver reliability of local progressive disease (L-PD) determination using two major radiological response evaluation criteria systems (Response evaluation Criteria in Solid Tumors (RECIST) and the European and American Osteosarcoma Study (EURAMOS)) in patients diagnosed with localized osteosarcoma (OS). Additionally, we describe the outcomes of patients determined to experience L-PD. Materials and Methods: Forty-seven patients diagnosed with localized OS between 2000 and 2012 at our institution were identified. Paired magnetic resonance imaging of the primary tumor from diagnosis and post-neoadjuvant chemotherapy were blindly assessed by two experienced radiologists and determined L-PD as per RECIST and EURAMOS radiological criteria. Interobserver reliability was measured using the kappa statistic (&kappa ). The Kaplan Meier method and log-rank test was used to assess differences between groups. Results: Of 47 patients (median age at diagnosis 12.9 years), 16 (34%) had L-PD (by RECIST or EURAMOS radiological definition). There was less agreement between the radiologists using EURAMOS radiological criteria for L-PD (80.9%, &kappa = 0.48) than with RECIST criteria (97.9%, &kappa = 0.87). Patients with radiologically defined L-PD had a 5-year progression-free survival (PFS) of 55.6%, compared to a 5 year-PFS of 82.7% in the group of patients without L-PD (n = 31) (Log rank p = 0.0185). Conclusions: The interobserver reliability of L-PD determination is higher using RECIST than EURAMOS. RECIST can be considered for response assessment in OS clinical trials. The presence of L-PD was associated with worse outcomes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2b94a612c8b277387226b16d4c5390 http://europepmc.org/articles/PMC7767085 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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