IEIIS Meeting minireview: Bordetella evolution: lipid A and Toll-like receptor 4
| Autor: | Eric T. Harvill, Andrew Preston, Iain MacArthur, Paul B. Mann |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
0301 basic medicine
Models Molecular Bordetella pertussis Bordetella 030106 microbiology Immunology Context (language use) Microbiology Bordetella parapertussis Lipid A 03 medical and health sciences 0302 clinical medicine Species Specificity Humans Molecular Biology Bordetella Infections Toll-like receptor Bordetella bronchiseptica biology Cell Biology respiratory system biology.organism_classification respiratory tract diseases Toll-Like Receptor 4 Infectious Diseases Interaction with host 030215 immunology |
| Zdroj: | Journal of endotoxin research. 13(4) |
| ISSN: | 0968-0519 |
| Popis: | The evolution of Bordetella pertussis and Bordetella parapertussis from Bordetella bronchiseptica involved changes in host range and pathogenicity. Recent data suggest that the human-adapted Bordetella modified their interaction with host immune systems to effect these changes and that decreased stimulation of Toll-like receptor 4 (TLR4) by lipid A is central to this. We discuss Bordetella lipid A structure and genetics within the context of evolution and host immunity. |
| Databáze: | OpenAIRE |
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