Prediction of Recurrence in Operable Breast Cancer by Postoperative Changes in Prolactin Secretion
| Autor: | Franco Frigerio, Gabriele Tancini, Paolo Lissoni, Fernando Brivio, Sandro Barni, Antonio Ardizzoia, Franco Rovelli, Marina Cazzaniga |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
endocrine system Cancer Research medicine.medical_specialty endocrine system diseases Breast surgery medicine.medical_treatment Mammary gland Breast Neoplasms Disease-Free Survival Text mining Breast cancer Internal medicine medicine Humans Secretion Postoperative Period Neoplasm Metastasis skin and connective tissue diseases Aged business.industry General Medicine Middle Aged Prognosis medicine.disease Prolactin Endocrinology medicine.anatomical_structure Oncology Lymphatic Metastasis Multivariate Analysis Cancer research Regression Analysis Female Breast cancer cells business Biomarkers hormones hormone substitutes and hormone antagonists |
| Zdroj: | Oncology. 52:439-442 |
| ISSN: | 1423-0232 0030-2414 |
| DOI: | 10.1159/000227507 |
| Popis: | It has been demonstrated that breast surgery may induce prolactin (PRL) increase. Because of the potential stimulatory role of PRL on breast cancer cells, its postoperative increase may influence the prognosis of breast cancer patients. This study was performed to evaluate the influence of surgery-induced hyperprolactinemia on recurrence rate in operable breast cancer. The study included 250 consecutive breast cancer patients, clinical stage T1-3 N0-2M0, who were observed for a median follow-up of 72 months. Surgery-induced hyperprolactinemia occurred in 108/250 patients (43%). Irrespectively of node involvement, hormonal receptor, type of surgery and adjuvant therapies, the relapse rate was significantly higher in patients who had no surgery-induced hyperprolactinemia than in those with postoperative PRL increase (64/142 vs. 23/108; p0.001). This difference was also significant in relation to node status (N0:22/63 vs. 5/56, p0.001; N+:42/79 vs. 18/52, p0.05). The present study shows that a surgery-induced rise of PRL, despite its potential stimulation of cancer cell growth, is paradoxically associated with a longer disease-free survival in operable breast carcinoma in both patients with or without axillary node involvement. Moreover, this study suggests that the prognosis of node-negative patients who did not show postoperative hyperprolactinemia tends to be similar to that of patients with node involvement and surgery-induced PRL enhancement. Therefore, the lack of surgery-induced hyperprolactinemia would have to be grouped together with the unfavorable prognostic factors of breast cancer. |
| Databáze: | OpenAIRE |
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