Comparative Effectiveness of Various Eradication Regimens for Helicobacter Pylori Infection in the Northeastern Region of Poland
| Autor: | Justyna Wasielica-Berger, Patryk Gugnacki, Maryla Mlynarczyk, Pawel Rogalski, Agnieszka Swidnicka-Siergiejko, Stefania Antonowicz, Michalina Krzyzak, Dominik Maslach, Andrzej Dabrowski, Jaroslaw Daniluk |
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| Rok vydání: | 2022 |
| Předmět: |
Helicobacter pylori
Metronidazole Health Toxicology and Mutagenesis bismuth-containing quadruple therapy eradication levofloxacin-based triple therapy metronidazole-based triple therapy Poland Public Health Environmental and Occupational Health Humans Drug Therapy Combination Proton Pump Inhibitors Bismuth Anti-Bacterial Agents Helicobacter Infections Retrospective Studies |
| Zdroj: | International Journal of Environmental Research and Public Health; Volume 19; Issue 11; Pages: 6921 |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph19116921 |
| Popis: | Purpose: Due to the lack of systematic data on antibiotic sensitivity, the treatment of the highly prevalent and pathogenic Helicobacter pylori (H. pylori) infection still poses a significant problem. Therefore, the aim of our study was to compare the efficacy of the three most commonly used anti-H. pylori therapies in northeastern Poland. Patients and Methods: This was a retrospective, single-center study performed on 289 outpatients with an H. pylori infection. Patients received one of the following three treatment regimens: (1) bismuth quadruple therapy (BQT) for 10 days, (2) metronidazole-based triple therapy (M-TT) for 10 or 14 days, and (3) levofloxacin-based triple therapy (L-TT) for 10 or 14 days. Results: BQT, M-TT, and L-TT accounted for 93.2% of prescribed anti-H. pylori therapies. The overall success rate for all treatment regimens was 84.1% (243/289). The effectiveness of first- and second-line therapy was similar and reached 83.8% and 86.2%, respectively. The efficacy of the individual treatment regimens was as follows: (1) BQT—89.4% (84/94), (2) M-TT—80.6% (112/139) and 78.8% (26/33) for 10 and 14 days, respectively, and (3) L-TT—84.6% (11/13) and 100% (10/10) for 10 and 14 days, respectively. The overall duration of treatment and type and dose of proton pump inhibitor (PPI) had no effect on the treatment efficacy. Conclusions: In the northeastern part of Poland, 10-day BQT and 10- or 14-day L-TT are effective treatment regimens for H. pylori eradication and have appear to be superior to M-TT. Practitioners in our clinic followed mostly local anti-H. pylori therapy guidelines. |
| Databáze: | OpenAIRE |
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