Anticancer and Immunomodulatory Benefits of Taro (Colocasia esculenta) Corms, an Underexploited Tuber Crop
| Autor: | Anna Carolina Nitzsche Teixeira Fernandes Corrêa, V. M. F. Paschoalin, Erika Bertozzi de Aquino Mattos, Patricia R. Pereira, Maurício Afonso Verícimo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
resistant starch Antioxidant Bioactive molecules medicine.medical_treatment Anti-Inflammatory Agents Antineoplastic Agents Corm Review Biology Protective Agents Antioxidants Catalysis Inorganic Chemistry lcsh:Chemistry 03 medical and health sciences 0302 clinical medicine COX-2 down-regulation health-promoting compounds medicine Humans Immunologic Factors Physical and Theoretical Chemistry Molecular Biology metabolism modulation lcsh:QH301-705.5 Spectroscopy Traditional medicine Plant Extracts Organic Chemistry Feeding Behavior Nutrients General Medicine Computer Science Applications Colocasia esculenta Plant Tubers 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Polyphenol 030220 oncology & carcinogenesis taro dietary intervention Health Impact Assessment Colocasia |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 265, p 265 (2021) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Taro corms contain valuable bioactive molecules effective against cancer and cancer-related risk factors, such as carcinogens and biological agents, several pathophysiological conditions, including oxidative stress and inflammation, while controlling metabolic dysfunctions and boosting the immunological response. Such broad effects are achieved by the taro health-influencing compounds displaying antitumoral, antimutagenic, immunomodulatory, anti-inflammatory, antioxidant, anti-hyperglycemic, and anti-hyperlipidemic activities. Taro bioactivities are attributed to the combination of tarin, taro-4-I polysaccharide, taro polysaccharides 1 and 2 (TPS-1 and TPS-2), A-1/B-2 α-amylase inhibitors, monogalactosyldiacylglycerols (MGDGs), digalactosyldiacylglycerols (DGDGs), polyphenols, and nonphenolic antioxidants. Most of these compounds have been purified and successfully challenged in vitro and in vivo, proving their involvement in the aforementioned activities. Although these health-promoting effects have been recognized since ancient times, as well as other valuable features of taro for food profit, such as hypo-allergenicity, gluten-free, and carbohydrates with medium-glycemic index, taro crop remains underexploited. The popularization of taro intake should be considered a dietary intervention strategy to be applied to improve the overall health status of the organism and as supportive therapy to manage tumorigenesis. |
| Databáze: | OpenAIRE |
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