Effective protection of pigs against lethal Pseudorabies virus infection after a single injection of low-dose Sindbis-derived plasmids encoding PrV gB, gC and gD glycoproteins
| Autor: | Daniel Dory, Véronique Béven, André Jestin, Roland Cariolet, Anne-Marie Torché, Christophe Loizel, Philippe Blanchard |
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| Rok vydání: | 2004 |
| Předmět: |
animal diseases
viruses Genetic Vectors Pseudorabies Virulence Biology medicine.disease_cause Herpesviridae Virus Microbiology DNA vaccination Plasmid Viral Envelope Proteins Alphaherpesvirinae medicine Pseudorabies Vaccines Vaccines DNA Animals chemistry.chemical_classification Swine Diseases General Veterinary General Immunology and Microbiology Public Health Environmental and Occupational Health virus diseases biochemical phenomena metabolism and nutrition biology.organism_classification Virology Herpesvirus 1 Suid Infectious Diseases chemistry Molecular Medicine Glycoprotein |
| Zdroj: | Vaccine. 23(26) |
| ISSN: | 0264-410X |
| Popis: | This study compared protection of pigs against lethal Pseudorabies virus (PrV) infection induced by a single injection of various quantities of Sindbis virus-derived plasmids encoding PrV glycoproteins gB, gC and gD. Pigs were injected with 340, 68 or 13 microg of each plasmid. Few immune differences were observed after DNA injection and more importantly the pigs of the three groups were equally protected against virulent PrV infection. Single-shot injection of 13 microg of each PrV glycoprotein encoding Sindbis virus-derived plasmid is able to effectively protect pigs from PrV infection. |
| Databáze: | OpenAIRE |
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