The biochemical effects of nano tamoxifen and some bioactive components in experimental breast cancer
| Autor: | Dina Mostafa Mohammed, Abdou O. Abdelhamid, Afaf Ezzat, Amal S. Abd El Azeem, Mostafa K. El Awady |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Lipid Peroxides Receptor ErbB-2 DMBA Apoptosis Pharmacology Significant elevation Antioxidants Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Breast cancer Mammary Glands Animal Nano medicine Animals natural sciences skin and connective tissue diseases Lipid peroxide Chemistry technology industry and agriculture Deoxyguanosine Mammary Neoplasms Experimental Estrogens General Medicine medicine.disease Surgery Antioxidant capacity Tamoxifen 030104 developmental biology 8-Hydroxy-2'-Deoxyguanosine 030220 oncology & carcinogenesis Nanoparticles Female medicine.drug |
| Zdroj: | Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 95 |
| ISSN: | 1950-6007 |
| Popis: | The effect of nano tamoxifen and some bioactive components such as yeast, isoflavone, and silymarin on the level of resistance and prevention of breast cancer progression in experimental animals is the target of this study. Thirty female Sprague-Dawley rats received a single medication dosage of 7,12-dimethylbenz[a]anthracene (DMBA) intragastrically. After fourteen days of DMBA admission, the procedure protocol started out. Finally, all the experimental results evaluated, tabulated and statistically analyzed. The results demonstrated a highly significant elevation in the 8-OHdG level in group 1 (nano yeast) and 3 (nano silymarin) while the results demonstrated a highly significant reduction in group 2 (nano tamoxifen). The apoptosis results demonstrated a significant elevation in group 3 (nano silymarin) where appeared significant reduction in group 4 (nano isoflavone). ErbB-2 results demonstrated a significant elevation in group 2 (nano tamoxifen) and a significant reduction in each of group 3 (nano silymarin) and 4 (nano isoflavone). The lipid peroxide level demonstrated an extremely significant reduction in group 4 (nano isoflavone). And a significant reduction of total antioxidant was observed in group 3 (nano silymarin) in comparison to injected animals control. This may be considered a new vision and strategy to resist breast cancer disease or prevent progression. |
| Databáze: | OpenAIRE |
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